Gastric cancer (GC) is a lethal disease due to heterogeneity and complexity from the point of view of epidemiology, epidemiology and public health policy and biological behaviour. Despite recent advances in the research field on the molecular and cellular characterisation of GC, the clinical outcomes have been ominous. Perhaps the unceasing research in future years, focusing on spatial omics, has revolutionary potential for transforming the conception and understanding of GC mechanisms, thereby enabling the discovery of targeted therapies that are most effective in improving survival. Under these circumstances, this review article lays the groundwork for an update of spatial omics, offering a comprehensive vision and its implications for understanding the landscape of GC research. Moreover, it highlights the recent advances and breakthroughs in heterogeneity and immunosuppressive tumour microenvironment.