ecancermedicalscience

Review

Cervical cancer: a meta-analysis, therapy and future of nanomedicine

24 Sep 2020
Jeaneen Venkatas, Moganavelli Singh

Cervical cancer is one of the leading causes of female death, with an annual mortality rate exceeding 200,000 in developing communities. Despite the past decade bearing witness to a reduction in cervical cancer cases throughout developed countries, the prevalence in developing countries continues to rapidly rise. The increase in cervical cancer cases is attributed to the lack of financial resources and the unavoidable risk factors of the disease. The means of traditional anticancer therapy are compromised by reduced drug potency, non-specificity, negative side effects and the development of multiple drug resistance, which leads to a decrease in the long-term anticancer therapeutic efficacy. Recent advances in nanomedicine have elucidated the potential of nanoparticles to reduce the side effects and improve the survival rate of patients, by enhancing selective delivery and uptake of photosensitive, therapeutic and genetic material to cervical cancer cells, thereby enhancing antitumour efficiency. This review paper analyses the risk factors and epidemiology of cervical cancer globally, and especially in developing communities, whilst demonstrating the enhanced anticancer treatment using selected nanoparticles.

Related Articles

Charles M Balch, Ning Liao, Denis S C Lam, Jeffrey N Weitzel, Rui-Hua Xu, Gerhardt Attard, Paul A Bunn, Alexander M M Eggermont, Jie He, Yuko Kitagawa, Soon Thye Lim, Eduardo Cazap, Bernard Esquivel, Xianqun Fan, Louis W C Chow, Edward S F Liu, Hector Martinez Said, John E Niederhuber, Isabel T Rubio, Ashraf Saad Zaghloul, Oscar G Arrieta, Riccardo A Audisio, Geerard L Beets, Felipe J F Coimbra, Jorge E Gallardo, Judy E Garber, Alessandro Gronchi, Volker Heinemann, Allison W Kurian, Miriam Mutebi, Masaki Mori, Funmi I Olopade, Piotr Rutkowski, Mansoor Saleh, William M Sanchez, Raymond Sawaya, John F Thompson, Gerald Tumusiime, Carlos S Vallejos, David C Whiteman, YiLong Wu, King-David T Yawe, Nayef Awad Al Zahrani, Odysseas Zoras, Banu K Arun, Carol J Fabian, Jeffrey E Gershenwald, William J Gradishar, Jin He, V Suzanne Kimberg, Ronald M K Lam, Victor H F Lee, Domenica Lorusso, Tony S K Mok, N D Perrier, Hope S Rugo, Cornelia Ulrich, Chandrakanth Are
Josepmilly Del Valle Peña Colmenares, Wladimir José Villegas Rodríguez, Osama Bahsas Zaky, Carlos Eduardo Martínez, Douglas José Angulo Herrera
Ally H Mwanga, Jeanine Justiniano, Eric M Mbuguje, Balowa Musa, Deogratius B Mwanakulya, Andrew Swallow, Edith Kimambo, Eva Uiso, Swaleh Pazi, Latifa Rajab, Nashivai E Kivuyo, Larry Akoko, Azza Naif, Advera Ngaiza, Sara Nyagabona, Jerry Ndumbalo, Amos R Mwakigonja, Jim E Littlejohn, Seif Wibonela, Cameron E Gaskill
Juzzel Ian Zerrudo, Patrick Vincent Aquino, Christian Joseph Tagal, Ma Erica Valdeabella, Christian Norwiz Buenviaje