ecancermedicalscience

Case Report

Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide

8 Sep 2017
Gaetano Paone, Simona Di Lascio, Andrea Azzola, Luca Mazzucchelli, Olivia Pagani

A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent 18F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and transbronchial lung biopsy was performed. Histological results were compatible with sarcoidosis. The patient began steroid treatment and 6 weeks after a PET-CT showed normalisation of both splenic and nodal uptake. In our case, 18F-FDG PET-CT has been useful in detecting a rare case of splenic sarcoidosis without typical nodular lesions on CT images, impacting the patient’s treatment and prognosis.

Related Articles

Manuel Bazan, Claudia Gutiérrez-Villamil, Amalia Peix, Saurabh Malhotra, Fernando Dettori, Roberto N Agüero, Belén Flores, Claudio Tinoco Mesquita, Enrique Hiplan, Teresa Massardo, Isabel Berrocal, José A Coss, Verónica Gómez, María C Fonseca, Karla Abadí, Adriana Puente, Víctor Rosales, Luis F Chen, Yariela Herrera, Marina Arnal, Aurelio Mendoza, Omar Alonso, Jorge E Aguiar, Carla Cueva, Enrique Estrada, Diana Páez
Sudarshan Govender, Tamsin K Phillips, Fiona M Walter, Sarah Day, Bothwell Guzha, Suzanne E Scott, Zvavahera M Chirenje, John E Ataguba, Nomonde Mbatani, Nazia Fakie, Jennifer Moodley
Cassio Murilo Hidalgo Filho, Mateus Marinho Nogueira Soares, Wesley Antonio Lopes de Lima, Laura Testa, Marcela Simonis Martins Ferrari, Renata Colombo Bonadio
Nairica Eurico Rebello, Anita Spadigam, Anita Dhupar, Jochima Cota, Vikas Dhupar