ecancermedicalscience

Case Report

Unusual case of splenic sarcoidosis without morphological lesions detected by PET-CT in a patient with breast cancer: functional imaging between pitfalls and therapeutic guide

8 Sep 2017
Gaetano Paone, Simona Di Lascio, Andrea Azzola, Luca Mazzucchelli, Olivia Pagani

A 60-year-old woman under treatment with letrozole for metastatic breast cancer underwent 18F-FDG PET-CT for restaging. A new widespread intense splenic FDG uptake without nodular lesions and multiple FDG-avid mediastinal and abdominal nodes were observed. Based on these findings, a nodal and transbronchial lung biopsy was performed. Histological results were compatible with sarcoidosis. The patient began steroid treatment and 6 weeks after a PET-CT showed normalisation of both splenic and nodal uptake. In our case, 18F-FDG PET-CT has been useful in detecting a rare case of splenic sarcoidosis without typical nodular lesions on CT images, impacting the patient’s treatment and prognosis.

Related Articles

Soumitra Shankar Datta, Jigeesha Ghosh, Dishari Choudhury, Suvro Sankha Datta, Prateek Jain, Sakshi Adhia, Indranil Mallick, Sanjit Agrawal, Sanjay Garg, Shouriyo Ghosh, Arijit Nag, Arnab Mukherjee, Soumita Ghose, Sayantani Das, Rima Mukherjee, Sujit Sarkhel, Pattatheyil Arun
Israel Fernandez-Pineda, Simone de Campos Vieira Abib, Tristan Boam, Diego Aspiazu Salinas, Samer Michael, Justin Ted Gerstle, Steven Warmann, Jorg Fuchs, Alyssa Stetson, Gloria Gonzalez, Greg Tiao, Timothy B. Lautz, Rodrigo Chaves Ribeiro, Roshni Dasgupta, Jaime Shalkow-Klincovstein, Cristian Puerta, Andrew M. Davidoff, Marianna Cornet, Julien Grosman, Aurore Pire, Sabine Sarnacki, Thomas Blanc, Abdelhafeez H Abdelhafeez
Ajay Kumar Yadav, Anshuman Pandey, Rahul Singh, Hareesh Shanthappa Nellikoppad, Bhanu Pratap Singh
Charles M Balch, Ning Liao, Dennis S C Lam, Jeffrey N Weitzel, Rui-Hua Xu, Gerhardt Attard, Paul A Bunn, Alexander M M Eggermont, Jie He, Yuko Kitagawa, Soon Thye Lim, Eduardo Cazap, Bernard Esquivel, Xianqun Fan, Louis W C Chow, Edward S F Liu, Hector Martinez Said, John E Niederhuber, Isabel T Rubio, Ashraf Saad Zaghloul, Oscar G Arrieta, Riccardo A Audisio, Geerard L Beets, Felipe J F Coimbra, Jorge E Gallardo, Judy E Garber, Alessandro Gronchi, Volker Heinemann, Allison W Kurian, Miriam Mutebi, Masaki Mori, Funmi I Olopade, Piotr Rutkowski, Mansoor Saleh, William M Sanchez, Raymond Sawaya, John F Thompson, Gerald Tumusiime, Carlos S Vallejos, David C Whiteman, YiLong Wu, King-David T Yawe, Nayef Awad Al Zahrani, Odysseas Zoras, Banu K Arun, Carol J Fabian, Jeffrey E Gershenwald, William J Gradishar, Jin He, V Suzanne Kimberg, Ronald M K Lam, Victor H F Lee, Domenica Lorusso, Tony S K Mok, N D Perrier, Hope S Rugo, Cornelia Ulrich, Chandrakanth Are, J Vignat, I Soerjomataram