ecancermedicalscience

Case Report

Collision tumour of large-cell neuroendocrine carcinoma and adenocarcinoma in the stomach: A case report

29 Jan 2016
Eduardo Payet, Pau I Pilco, Jaime Montes, Alejandra Cordero-Morales, Maria Jose Savitzky, Karoline Stenning-Persivale

Concurrence of adenocarcinoma and large-cell neuroendocrine carcinoma of the stomach is a rare condition. Here, we report a case of gastric collision tumour with large-cell neuroendocrine carcinoma and adenocarcinoma. A 71-year-old Peruvian man presented with nausea, epigastric pain, and weight loss for seven months. An Endoscopic evaluation revealed a huge ulcerative and infiltrative mass in the upper and middle third of the stomach. The patient underwent a D2 total gastrectomy. Microscopically, two separated and attached ulcerative lesions were recognised. The proximal to the cardial lesion showed neuroendocrine morphology and immunoreactivity for synaptophysin, and the other a moderated tubular adenocarcinoma Borrmann type III. Both lesions invaded serosa and lymph nodes metastases were found in 17 of 41 lymph nodes retrieved (one lymph node with neuroendocrine metastatic deposits).

Related Articles

Groesbeck Preer Parham, Kabongo Mukuta Mathieu, Tankoy Gombo YouYou, Michael L Hicks, Ronda Henry-Tillman, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Leeya Pinder, Maya M Hicks, Louis Kanda, Mirielle Kanda
Michael L Hicks, Alex Mutombo, Tankoy Gombo YouYou, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Kabongo Mukuta Mathieu, Ronda Henry-Tillman, Dorothy Lombe, Maya M Hicks, Leeya Pinder, Louis Kanda, Mirielle Kanda, Groesbeck P Parham
Kabongo Mukuta Mathieu, Tankoy Gombo YouYou, Michael L Hicks, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Leeya Pinder, Maya M Hicks, Louis Kanda, Mirielle Kanda, Groesbeck P Parham, Ronda Henry-Tillman
Tankoy Gombo YouYou, Kabongo Mukuta Mathieu, Michael L Hicks, Ronda Henry-Tillman, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Maya M Hicks, Leeya Pinder, Louis Kanda, Mirielle Kanda, Groesbeck P Parham
Mauricio Fernandes, Tiago Pugliese Branco, Maria Clara Navarro Fernandez, Carolina Paparelli, Mariana Sarkis Braz, Carolina Sassaki Kishimoto, Helena Maria de Freitas Medeiros, Karen Ebina, Luciana Regina Bertini Cabral, Simone Nagashima, Silvia Amaral de Avó Cortizo, Fabíola Borges, Mariana Ribeiro Monteiro, Ana Beatriz Kinupe Abrahao, Raphael Brandão Moreira, Alze Pereira dos Santos Tavares, Pedro Nazareth Aguiar Jr
Ranjeeta Subedi, Atul Budukh, Sandhya Chapagain, Pradip Gyanwali, Bishal Gyawali, Kopila Khadka, Chanda Thakur, Uma Dahal, Rajesh Dikshit, Anjani Kumar Jha, Meghnath Dhimal