ecancermedicalscience

Research

Subtypes of minimal residual disease and outcome for stage II colon cancer treated by surgery alone

8 Oct 2020
Nigel P Murray, Sócrates Aedo, Ricardo Villalon, Vidal Albarran, Shenda Orrego, Eghon Guzman

Introduction: Twenty-five percent of stage II colon cancer (CC) patients relapse within 5 years due to minimal residual disease (MRD) not eliminated by surgery. We hypothesise that subtypes of MRD, defined by circulating tumour cells (CTCs) and bone marrow micrometastasis (mM), have different types and kinetics of relapse.

Methods and patients: One month after surgery, blood and bone marrow samples were taken to detect CTCs and mM using immunocytochemistry with anti-carcinoembryonic antigen (CEA). Follow-up was for up to 5 years or relapse. Disease-free survival curves using Kaplan–Meier (DFS) and restricted mean disease-free survival times (RMST) were calculated for three prognostic groups: A: MRD (−), B: mM ( ) CTC (−) MRD and C: CTC ( ) MRD.

Results: One hundred and eighty-one patients (82 men) have participated, mean age was 68 years and median follow-up was 4.04 years (A (N = 105), B (N = 36) and C (N = 40)). For the whole cohort of 5 years, DFS was 70%, median DFS has not reached (Groups A: 98%, B: 63% and C: 7%) and median DFS for Groups A and B have not reached. RMST for the whole cohort of 4.1 years, Group A was 4.9 years, B was 4.1 years and C was 1.7 years. Serum CEA was significantly higher in Group C. No significant differences for sex, age or high-risk adverse prognostic factors between groups were detected.

Conclusions: MRD subtypes define relapse patterns and may be useful to define the risk of relapse in stage II CC patients, in which patients may benefit or not from additional therapy and warrants further studies with a larger number of patients.

Article metrics: 36 views
36

Related Articles

Renata D’Alpino Peixoto, Duilio R Rocha-Filho, Rui F Weschenfelder, Juliana FM Rego, Rachel Riechelmann, Anelisa K Coutinho, Gustavo S Fernandes, Alexandre A Jacome, Aline C Andrade, Andre M Murad, Celso AL Mello, Diego SCG Miguel, Diogo BD Gomes, Douglas J Racy, Eduardo D Moraes, Eduardo H Akaishi, Elisangela S Carvalho, Evandro S Mello, Fauze Maluf Filho, Felipe JF Coimbra, Fernanda C Capareli, Fernando F Arruda, Fernando MAC Vieira, Flavio R Takeda, Guilherme CC Cotti, Guilherme LS Pereira, Gustavo A Paulo, Héber SC Ribeiro, Laercio G Lourenco, Marcela Crosara, Marcelo G Toneto, Marcos B Oliveira, Maria de Lourdes Oliveira, Maria Dirlei Begnami, Nora M Forones, Osmar Yagi, Patricia Ashton-Prolla, Patricia B Aguillar, Paulo CG Amaral, Paulo M Hoff, Raphael LC Araujo, Raphael P Di Paula Filho, Rene C Gansl, Roberto A Gil, Tulio EF Pfiffer, Tulio Souza, Ulysses Ribeiro Jr, Victor Hugo f Jesus, Wilson L Costa Jr, Gabriel Prolla
Silvia Francesca Maria Pizzoli, Giulia Marton, Paola Pricolo, Serena Oliveri, Paul Summers, Giuseppe Petralia, Gabriella Pravettoni
G Luis Pendola, Roberto Elizalde, Pablo Sitic Vargas, José Caicedo Mallarino, Eduardo Gonzalez, José Parada, Mauricio Camus, Ricardo Schwartz, Enrique Bargalló, Ruffo Freitas, Mauricio Magalhaes Costa, Vilmar Marques de Oliveira, Paula Escobar, Miguel Oller, Luis Fernando Viaña, Antonio Jurado Bambino, Gustavo Sarria, Francisco Terrier, Roger Corrales, Valeria Sanabria, Juan Carlos Rodríguez Agostini, Gonzalo Vargas Chacón, Víctor Manuel Pérez, Verónica Avilés, José Galarreta, Guillermo Laviña, Jorge Pérez Fuentes, Lía Bueso de Castellanos, Bolívar Arboleda Osorio, Herbert Castillo, Claudia Figueroa
Fabiana CAP Lisboa, Roberta B Silva, Keitty R C de Andrade, Lucimara PC Veras, Ana Claudia MG Figueiredo, Maurício G Pereira