ecancermedicalscience

Case Report

Liver failure due to relapsed myeloma and hepatic iron overload

30 Apr 2020
Chakra P Chaulagain, Adalberto Gonzalez, Isaac Goldszer, Luis Caraballo, James E Hoffman, Leah Elson, Maria-Julia Diacovo

Multiple myeloma is a hematologic malignancy that classically manifests with hypercalcaemia, renal insufficiency, anaemia and lytic bone lesions. Liver dysfunction in multiple myeloma is a lesser known complication that occurs through biliary obstruction, liver infiltration by plasma cells, amyloid/light chain deposition or due to liver injury from medications. Although transfusion-related hepatic iron overload—leading to significant liver disease—is a recognised complication in certain hematologic malignancies, little is known about transfusional iron overload in patients with multiple myeloma. We present a case of a 49-year-old female with relapsed/refractory multiple myeloma who presented with rapid onset liver failure, due to both iron deposition and malignant plasma cell infiltration of the liver as a terminal event. A review of the literature on hepatic complications in multiple myeloma patients is presented.

Related Articles

Yasmim Portela Machado de Aguiar, Adjanny Estela Santos de Souza, Christian Diniz Lima e Silva, Sândrea Ozane do Carmo Queiroz
Arnab Mukherjee, Chitralekha Bhowmick, Shreshta Chattopadhyay, Mohamed Abdul Kathar, Moitri Bhattacharyya, Shazia Nasreen, Prateek Jain, Pattatheyil Arun, Soumitra Shankar Datta
Goutam Santosh Panda, Vanita Noronha, Subhash Yadav, Amit Joshi, Vijay Patil, Nandini Menon, Rajiv Kumar, Amit Janu, Abhishek Mahajan, Nilendu Purandare, Jai Prakash Agarwal, George Karimundackal, Kumar Prabhash