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Abstract | Full HTML Article | PDF | Spanish ecancer 9 534 / https://doi.org/10.3332/ecancer.2015.534

Special Issue

The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections

Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.

Keywords: Ubc9, SUMO, biomarker, HPV, LSIL, HSIL, cervical cancer

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Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation