ecancermedicalscience

Special Issue

The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections

29 Apr 2015
Domenico Mattoscio, Chiara Casadio, Marzia Fumagalli, Mario Sideri, Susanna Chiocca

Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.