ecancermedicalscience

Research

Intra-operative measurement of tumour size in breast cancer and its comparison with other methods: a prospective study

26 Sep 2008
VP Verma, N Kaur, N Agarwal, SK Bhargava, UR Singh, S Saha, A Raheja

Accurate measurement of breast tumour size determines staging and prognosis. Discrepancies amongst clinical examination (CE), ultrasonography (USG), mammography, pathological examination (PE) and magnetic resonance imaging have been reported. However, few studies have evaluated changes in breast tumour size from the operating table to the laboratory.

Objectives and methods: A prospective study was designed to assess the intra-operative (IO) tumour size in 29 patients of breast cancer presenting to a tertiary care centre in Delhi and to compare it with CE, USG and PE.

Observations and results: Twenty-nine patients (mean age: 47 years), presenting with invasive duct carcinoma (stage IIIA: 31%, stage IIB: 28%), were included in the study. Comparison with mean IO (4.2 cm) revealed that both USG and PE underestimated tumour size by a mean of 0.35 cm (8.4%) and 0.45 cm (10.7%), respectively, in most patients. CE tended to overestimate size by 0.82 cm (19.8%). All three modalities showed statistically significant correlation with IO (maximum Pearson's correlation coefficient for PE=0.937, p<0.001; R2=0.877, maximum for PE). Two-way analysis of variance revealed mean difference in size to be statistically significant (p=0.000) only between CE and IO.

Discussion: Formalin processing causes changes in tumour dimensions in the breast, causing reduction in tumour size. It may also have a bearing on the assessment of surgical margins in breast conservation surgery. Immediate post-operative measurement of the specimen is ideal. Protocols for specimen fixation should be standardised.

Article metrics: 1817 views
734
1083

Related Articles

Kristen Cagino, Daniel Levitan, Nina Schatz-Siemers, Rasa Zarnegar, Eloise Chapman-Davis, Kevin Holcomb, Melissa Frey
Monique Binotto, Tomás Reinert, Gustavo Werutsky, Facundo Zaffaroni, Gilberto Schwartsmann
Cristóbal Maiz, Fernando Silva, Francisco Domínguez, Héctor Galindo, Mauricio Camus, Augusto León, David Oddó, Alejandra Villarroel, Dravna Razmilic, María Elena Navarro, Lidia Medina, Tomás Merino, Eugenio Vines, José Peña, Daniela Maldonado, Mauricio P Pinto, Francisco Acevedo, Cesar Sánchez
William T Tran, Carolina Ibáñez, Mauricio P Pinto, Cesar Sánchez, Gregory J Czarnota, Tomás Merino
Catarina Marchon da Silva, Denis Shimba, Denise Oishi, Allyne Cagnacci, Ana Carolina Ribeiro Chaves de Gouvea, Felipe Ades