ecancermedicalscience

Research

Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer

15 Jan 2019
Katerin Rojas L, Lucía Trilla-Fuertes, Angelo Gámez-Pozo, Cristina Chiva, Juan Sepúlveda, Luis Manso, Guillermo Prado-Vázquez, Andrea Zapater-Moros, Rocío López-Vacas, María Ferrer-Gómez, César Mendiola, Enrique Espinosa, Eduard Sabidó, Eva Ciruelos, Juan Ángel Fresno Vara

Background: Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)–which are associated with minor survival rates—lack markers predictive of response to anticancer drugs. Triple negative tumours frequently metastasise to the central nervous system (CNS).

Objective: The main objective of this study was to study differences in tumour protein expression between patients with CNS metastases and those without this kind of spread, and propose new biomarkers.

Methods: A retrospective study was performed. Targeted proteomics and statistical analyses were used to identify possible biomarkers.

Results: Proteins were quantified by a targeted proteomics approach and protein expression data were successfully obtained from 51 triple negative formalin-fixed paraffin-embedded samples. ISG15, THBS1 and AP1M1 were identified as possible biomarkers related with CNS metastasis development.

Conclusions: Three possible biomarkers associated with CNS metastases in TNBC tumours were identified: ISG15, THBS1 and AP1M1. They may become markers predicting the appearance of CNS infiltration in triple negative BC.

Related Articles

Francis Okongo, Catherine Amuge, Alfred Jatho, Nixon Niyonzima, David Martin Ogwang, Jackson Orem
Carlos A. Castaneda, Miluska Castillo, Joselyn Sanchez, Luis Bernabe, Katherin Tello, Nancy Suarez, Raul Alatrista, Ximena Quiroz-Gil, Alexandra Granda-Oblitas, Javier Enciso, Nathaly Enciso, Henry L Gomez
Somnath Roy, Sreejata Raychaudhuri, Bivas Biswas, Deepak Dabkara, Arnab Bhattacherjee, Sandip Ganguly, Joydeep Ghosh, Yesha Sandipbhai Patel, Souhita Pal, Jagriti Karmakar, Anindita Mitra, Sujoy Gupta
Natalia Camejo, Camila Montenegro, Dahiana Amarillo, Cecilia Castillo, Gabriel Krygier
Gonzalo Javier Ziegler-Rodriguez, Miguel Ángel Pinillos Portella, Gabriel De la Cruz Ku, Sheila Eunice Vílchez Santillan, Jorge Dunstan Yataco, José Antonio Galarreta Zegarra, Gabriela Calderón Valencia, José Manuel Cotrina Concha