ecancermedicalscience

Special Issue

Oxidative stress and the unfulfilled promises of antioxidant agents

23 Jul 2015
Marco Giorgio

It is well known that aging and its associated diseases, including cancer, are triggered by oxidative damage to biological macromolecules. However, antioxidant compounds are still disappointingly distant from any clinical application, so that Jim Watson has declared that antioxidant supplementation may have caused more cancers than it has prevented Watson J ((2013) Oxidants, antioxidants and the current incurability of metastatic cancers Open Biol 3 DOI: 10.1098/rsob.120144).

To clarify this paradox, here, we describe the mechanisms of oxidative stress focusing in particular on redox balance and physiological oxidative signals.

Related Articles

Ghazal Tansir, Sameer Rastogi, Sravan Kumar Dubasi, Sindhu Chitikela, Lavu Rohit Reddy, Adarsh Barwad, Ankur Goyal
Tabassum Wadasadawala, Roshankumar Patil, Johnny Carlton, Shalini Verma, Namita Umesh, Pallavi Rane, Rajiv Sarin, Rima Pathak, Jyoti Bajpai, Nita Nair, Tanuja Shet, Ramneet Kaur
Ally Mwanga, Eric Mbuguje, Jared Alswang, Nathan Brand, Andrew Swallow, Deogratius Beda Mwanakulya, Charles Pallangyo, Seif Wibonela, Eva Uiso, William Kitua, Saleh Pazi
Uchenna Simon Ezenkwa, Mohammed Ibrahim Imam, Maimuna Orahachi Yusuf, Abdullahi Sani Giade, Iragbogie Al-Mustapha Imoudu, Dauda Abubakar Katagum, Bala Muhammad Audu
Abhinav Bansal, Ekta Dhamija, Sheragaru Hanumanthappa Chandrashekhara, Ranjit Kumar Sahoo
Hassan Abdelilah Tafenzi, Farah Choulli, Anass Baladi, Ismail Essaadi, Rhizlane Belbaraka