ecancermedicalscience

Special Issue

Oxidative stress and the unfulfilled promises of antioxidant agents

23 Jul 2015
Marco Giorgio

It is well known that aging and its associated diseases, including cancer, are triggered by oxidative damage to biological macromolecules. However, antioxidant compounds are still disappointingly distant from any clinical application, so that Jim Watson has declared that antioxidant supplementation may have caused more cancers than it has prevented Watson J ((2013) Oxidants, antioxidants and the current incurability of metastatic cancers Open Biol 3 DOI: 10.1098/rsob.120144).

To clarify this paradox, here, we describe the mechanisms of oxidative stress focusing in particular on redox balance and physiological oxidative signals.

Related Articles

Marianne Gnanamuttupulle, Oliver Henke, Shilanaiman Hilary Ntundu, Furaha Serventi, Leila E Mwakipunda, Patrick Amsi, Alex Mremi, Kondo Chilonga, David Msuya, Samuel G Chugulu
Prisca O Adejumo, Toyin IG Aniagwu, Olutosin A Awolude, Abiodun O Oni, Olubunmi O Ajayi, Omolara Fagbenle, Dasola Ogungbade, Makayla Kochheiser, Temidayo Ogundiran, Olufunmilayo I Olopade
Akhil Kapoor, Vanita Noronha, Amit Joshi, Vijay M Patil, Nandini Menon, Rajesh Bollam, Vikas Talreja, Supriya Goud, Sucheta More, Leena Solanki, Srushti Shah, Anuradha Chougule, Abhishek Mahajan, Kumar Prabhash
Yazmín A Ramírez-Galván, Servando Cardona-Huerta, Guillermo Elizondo-Riojas, Alberto Montemayor-Martínez, Jesús I Morales-Escajeda, Carlos E Herrera-Peña
Juliet O Offor, Kehinde S Okunade, Bamidele A Iwalokun, Ayodeji A Oluwole, Rose I Anorlu
Isália Miguel, Fátima Rodrigues, Sofia Fragoso, João Freixo, Ana Clara, Ana Luis, Sandra Bento, Mariana Fernandes, Filipe Bacelar, Sara Câmara, Joana Parreira, Teresa Duarte, Paula Rodrigues, Sidónia Santos, Fátima Vaz