ecancermedicalscience

Special Issue

Why does obesity promote cancer? Epidemiology, biology, and open questions

23 Jul 2015
Luca Mazzarella

The association between obesity and/or metabolic syndrome and an elevated mortality from cancer has been confirmed by an astonishing number of studies across nations and ethnicities, such that obesity is now recognised to be among the most prominent cancer risk factors worldwide.

Despite this overwhelming evidence and the societal impact of obesity, we know surprisingly little about the underlying molecular mechanisms. This knowledge gap is a major obstacle to the implementation of effective lifestyle change policies. As the scientific community is insecure on what messages it should deliver, administrators are uncertain as to what exactly to recommend, and consumers are confused about whom to believe. This leaves the field flooded with pseudo-scientific recommendations that are hard to eradicate.

In this review, I will provide a summary of the existing epidemiological and mechanistic evidence on the relationship between systemic metabolism and cancer, highlighting debated issues and ongoing investigations.

Related Articles

Groesbeck Preer Parham, Kabongo Mukuta Mathieu, Tankoy Gombo YouYou, Michael L Hicks, Ronda Henry-Tillman, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Leeya Pinder, Maya M Hicks, Louis Kanda, Mirielle Kanda
Kabongo Mukuta Mathieu, Tankoy Gombo YouYou, Michael L Hicks, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Leeya Pinder, Maya M Hicks, Louis Kanda, Mirielle Kanda, Groesbeck P Parham, Ronda Henry-Tillman
Tankoy Gombo YouYou, Kabongo Mukuta Mathieu, Michael L Hicks, Ronda Henry-Tillman, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Maya M Hicks, Leeya Pinder, Louis Kanda, Mirielle Kanda, Groesbeck P Parham
Mauricio Fernandes, Tiago Pugliese Branco, Maria Clara Navarro Fernandez, Carolina Paparelli, Mariana Sarkis Braz, Carolina Sassaki Kishimoto, Helena Maria de Freitas Medeiros, Karen Ebina, Luciana Regina Bertini Cabral, Simone Nagashima, Silvia Amaral de Avó Cortizo, Fabíola Borges, Mariana Ribeiro Monteiro, Ana Beatriz Kinupe Abrahao, Raphael Brandão Moreira, Alze Pereira dos Santos Tavares, Pedro Nazareth Aguiar Jr
Ranjeeta Subedi, Atul Budukh, Sandhya Chapagain, Pradip Gyanwali, Bishal Gyawali, Kopila Khadka, Chanda Thakur, Uma Dahal, Rajesh Dikshit, Anjani Kumar Jha, Meghnath Dhimal
Suzanne T Nethan, Dhirendra N Sinha, Ashwini Kedar, Vipin Kumar, Shashi Sharma, Roopa Hariprasad, Ravi Mehrotra