ecancermedicalscience

Clinical Study

Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent

26 Nov 2014
Pan Pantziarka, Gauthier Bouche, Lydie Meheus, Vidula Sukhatme, Vikas P Sukhatme

Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised and discussed in relation to a number of distinct mechanisms of action. Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. Furthermore, there is compelling evidence that cimetidine administration during the peri-operative period may provide a survival benefit in some cancers. A number of possible combinations with other drugs are discussed in the supplementary material accompanying this paper.

Article metrics: 35302 views
8106
27196

Related Articles

Lorenzo Dottorini, Italo Sarno, Pasquale Scopelliti, Gianluca Cotroneo, Maribel Duluc, Alessandro Iaculli, Nicola Giuntini, Federica Brena, Giuseppe Nastasi
Julia Downing, Nixon Niyonzima, Sam Guma, Mwazi Batuli, Rose Kiwanuka, Innocent Atuhe, Zaitun Nalukwago, Mark Mwesiga, Warren Phipps, Henry Ddungu
Aline F Fares, Daniel V Araujo, Vinicius Calsavara, Augusto Obuti Saito, Maria Nirvana Formiga, Aldo A Dettino, Stenio Zequi, Walter H da Costa, Isabela W Cunha