ecancermedicalscience

Clinical Study

Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent

26 Nov 2014
Pan Pantziarka, Gauthier Bouche, Lydie Meheus, Vidula Sukhatme, Vikas P Sukhatme

Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised and discussed in relation to a number of distinct mechanisms of action. Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. Furthermore, there is compelling evidence that cimetidine administration during the peri-operative period may provide a survival benefit in some cancers. A number of possible combinations with other drugs are discussed in the supplementary material accompanying this paper.

Article metrics: 45424 views
9691
35733

Related Articles

Omobolaji O Ayandipo, Gabriel O Ogun, Olalekan J Adepoju, Ebenezer O Fatunla, Adefemi O Afolabi, Peter C Osuala, Temidayo O Ogundiran
Aida Raigon Ponferrada, Jose Luis Guerrero Orriach, Alfredo Malo Manso, Enrique Sepúlveda Haro, Salvador Romero Molina, Ana Fontaneda Heredia, Manolo Baena Lopez, Jose Cruz Mañas