ecancermedicalscience

Research

Contributory role of viral infection in congenital tumour development

9 Sep 2013
Maryam Monajemzadeh, Soheila Sarmadi, Maryam Moeini, Mohammad Vasei, Nima Rezaei, Ata Abbasi, Reza Shahsiah, Parin Tanzifi, Maryam Eghbali

Congenital tumours are a group of distinct infrequent disorders whose exact aetiologies have not clearly been understood so far. Viral infection seems to be one of the key factors involved in the carcinogenesis of certain tumours. This study was performed to assess whether viral DNAs are present in the congenital tumours or not. Nucleic acid from 31 congenital tumours was extracted. Detection of Epstein–Barr virus, Cytomegalovirus (CMV), adenovirus, Herpes simplex virus 1 (HSV1) and 2, Human herpes virus 6 (HHV6), and BK virus was performed using polymerase chain reaction. Viral nucleic acid was detected in eight subjects (25.8%), mostly adenovirus, CMV, and HHV6. Despite their low frequencies, a possible role could be identified for viral infections in tumour development or progression.

Related Articles

Jade Tso, Mustafa Al-Qaraghli, Susana Galeas, Mustafa Faleh Abidalhassan, Cameron E Gaskill
Samuel Santiago Parra Giraldo, Rut Amparo Vergara López, Haydee De La Hoz-Herazo, Enrique Carlos Ruiz Pla, Brayan Bayona-Pacheco, Juan Jose Espitia De La Hoz
Shama Pandey, Bishnu Dutta Paudel, Bibek Acharya, Sandhya Chapagain Acharya, Ambuj Karn, Saugat Poudyal, Manish Poudel, Pradeep Thapa, Jasmine Gurung, Ramila Shilpakar
Elily D Apumayta, Mario Buitrago, Marco Rioja, Sandra Alarcon, Jhonatanael Salvador, Eloy Ruiz
Julia Downing, Alexandra Daniels, Michael J McNeil, Mariam Ndagire, Gayatri Palat, Justin N Baker, Rima S Rassam