ecancermedicalscience

Research

Antiemetic activity of volatile oil from Mentha spicata and Mentha × piperita in chemotherapy-induced nausea and vomiting

31 Jan 2013
Z Tayarani-Najaran, E Talasaz-Firoozi, R Nasiri, N Jalali, MK Hassanzadeh

Background: This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha × piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV).

Methods: This was a randomised, double-blind clinical trial study. Prior to the study, patients were randomly assigned into four groups to receive M. spicata or M. × piperita. Statistical analysis included the χ2 test, relative risk, and Student’s t-test. Fifty courses were analysed for each group that met our eligibility criteria. The treatment and placebo groups applied essential oils of M. spicata, M. × piperita, or a placebo, while the control group continued with their previous antiemetic regimen. Patients or guardians recorded the number of emetic events, the intensity of nausea over 20 h of chemotherapy, as well as any possible adverse effects that occurred during this time.

Results: There was a significant reduction in the intensity and number of emetic events in the first 24 h with M. spicata and M. × piperita in both treatment groups (p < 0.05) when compared with the control and no adverse effects were reported. The cost of treatment was also reduced when essential oils were used.

Conclusion: M. spicata or M. × piperita essential oils are safe and effective for antiemetic treatment in patients, as well as being cost effective.

Related Articles

Amit Joshi, Vijay Maruti Patil, Vanita Noronha, Atanu Bhattacharjee, Nandini Menon, Amit Kumar, Parmanand Jain, Sadaf Mukadam, Avadhoot Shrinivas, Anjali Punia, Anuja Abhyankar, Amit Agarwal, Satvik Khaddar, Anu Rajpurohit, Kanteti Aditya Pavan Kumar, Rahul Ravind, Kishore Das, Vikas Talreja, Sachin Dhumal, Kumar Prabhash
Deepthi Valiyaveettil, Swapna Jilla, Jonnalagadda Mohan Krishna, Raja Kollu, Chandrasekhar Patil, Ranadheer Gupta
Vilma Adriana Tripodoro, Victoria Llanos, María Laura Daud, Pilar Muñoz, Eden Del Mar, Romina Tranier, Sol Sandjian, Silvina De Lellis, Juan Manuel Días, Alvaro Saurí, Gustavo Gabriel De Simone, Xavier Gómez-Batiste
Prasanth S Ariyannur, Reenu Anne Joy, Veena Menon, Roopa Rachel Paulose, Keechilat Pavithran, Damodaran M Vasudevan
Shridevi Subramaniam, Yek-Ching Kong, Hafizah Zaharah, Cuno SPM Uiterwaal, Andrea Richard, Nur Aishah Taib, Azura Deniel, Kok-Han Chee, Ros Suzanna Bustamam, Mee-Hoong See, Alan Fong, Cheng-Har Yip, Nirmala Bhoo-Pathy