ecancermedicalscience

Clinical Study

Comparative analysis of breast-conserving surgery versus reconstruction post-mastectomy: a BREAST-Q™ assessment

18 Mar 2026
Kristian Bugeja, Alexia Mercieca, Kristina Attard, Serkan Ilgun, John Agius

Objective: To compare patient-reported outcomes of breast-conserving surgery (BCS) and breast reconstruction post-mastectomy (BRPM) at Mater Dei Hospital using the BREAST-Q™ questionnaire, with a focus on multiple quality-of-life domains including satisfaction with breasts, psychosocial well-being, physical well-being, sexual well-being, fatigue, cancer worry and impact on work.

Methods: This retrospective audit analysed 46 patients treated between 2017 and 2020 at Mater Dei Hospital, Malta: 23 underwent BCS via wide local excision, and 23 underwent two-stage implant-based reconstruction following mastectomy. To reduce variability, only cases performed by a single breast surgeon were included, and age distributions were matched between groups. Patient-reported outcomes were assessed using the validated BREAST-Q™ version 1.0 questionnaire. Statistical comparisons between the BCS and BRPM groups were conducted using the Mann-Whitney U test.

Results: BCS patients reported higher scores in physical well-being (70.0% versus 64.6%, p = 0.01) and slightly better sexual well-being (73.3% vs versus 66.7%, p = 0.83), while BRPM patients showed higher psychosocial well-being (74.0% vs versus 69.4%, p = 0.17). Satisfaction with breast outcomes appeared higher in the BCS group when expressed as a percentage of the maximum possible score (83.5% vs versus 63.3%, p = 0.43), though raw scores favoured BRPM. Cancer worry, fatigue and impact on work scores were similar between groups, with no statistically significant differences.

Conclusion: Both BCS and BRPM yielded broadly comparable patient-reported outcomes across most domains. BRPM was associated with higher psychosocial well-being, while BCS patients experienced better physical and sexual well-being. The only statistically significant difference was found in physical well-being, favouring BCS. These findings underscore the importance of personalised counselling and shared decision-making to align surgical choices with patient values and expectations.

Related Articles

Tushar Ambekar, Amey Oak, Sivaranjini Kannusamy, Sandhya Cheulkar, Riya R John, Shalmali Chavan, Saket Mendhe, Supriya Kadam, Mamta Lade, Ganesh Balasubramanium, Ashwin Desouza, Avanish Saklani, Rajesh Dikshit, Pankaj Chaturvedi, Sudeep Gupta
Joshua Agilinko, Sonam Patel, Jogitha Selvarajah, Nicholas Tekkis, Mathew Vithayathil, Suzette Samlalsingh
Viviana Pinzón-Ramírez, Luis E Cueva-Cañola, Dilmareth E Natera, Helder Edgar Aldo-Chávez Olivera, Oscar Eduardo Camacho-Hernández, Andrea C Beltran-De la Fuente, Sergio Alexis Ramirez-Alvarez, Einstein Yhair Gallardo Cubas, Giomar Vilca Flores, Mauricio E Gamez, Leonardo Rangel Castilla
Pragyat Thakur, Nagarjun Ballari, Anureet Kaur, Tapas Kumar Dora, I Vedamanasa, Arshdeep Kaur, Ashish Gulia