ecancermedicalscience

Research

Evaluation of prognostic factors in patients undergoing first-line chemotherapy for advanced biliary tract cancer: a retrospective analysis from a South American cancer centre

17 Jan 2022
Tiago Cordeiro Felismino, Felipe Marcio Araujo Oliveira, Camilla Albina Zanco Fogassa, Silvia Nardozza Santerini, Victor Hugo Fonseca de Jesus, Rachel Simões Pimenta Riechelmann, Felipe José Fernandez Coimbra, Celso Abdon Lopes Mello

Introduction: Biliary tract cancers (BTCs) are rare tumours with regional differences. Prognostic factors are poorly understood. Gemcitabine + platinum (GP) is the standard first-line chemotherapy in metastatic patients. We aimed to search for prognostic factors in patients with advanced disease in a cancer centre in South America.

Methods: We conducted a retrospective analysis of patients with advanced BTC treated with chemotherapy. Variables were age (< or ≥70 years), Eastern Cooperative Oncology Group (ECOG) performance status (0/1 versus 2/3), gender, primary site (intrahepatic (IHC), extrahepatic (EHC), gallbladder (GB)), staging (locally advanced versus metastatic), metastatic sites, albumin (>3.5 g/dL versus <3.5 g/dL), biliary obstruction and first-line chemotherapy (GP, 5FU-based or single-agent). Cox regression method was used to explore factors.

Results: From 2010 to 2017, 104 patients were included. Median age was 62 years (32–86) and 22.1% were older than 70 years. Most patients had ECOG performance status 0/1 (63.4%), were female (51.9%) and were metastatic (82.7%). Bone metastases were found in 19.2%. Primary IHC, EHC and GB were 54.8%, 36.5% and 8.7%, respectively. GP was used by 79.8%. Median follow-up was 32.4 months. Median overall survival (mOS) was 11.4 months. In univariate analysis, male (p = 0.007), albumin < 3.5 g/dL (p = 0.001), biliary obstruction (p = 0.006), 5FU-based (p = 0.006) and single-agent (p < 0.0001) were associated with worse OS. ECOG performance status 2/3 (p = 0.058) and bone metastases (p = 0.051) were marginally related. In multivariate analysis, male (p = 0.003), bone metastases (p = 0.023), biliary obstruction (p = 0.001), 5FU-based (p = 0.016) and single-agent (p = 0.023) were independently associated with inferior OS.

Conclusion: In this retrospective study, we observed that male patients, bone metastases, biliary obstruction and regimens other than GP had worse survival. Larger studies should be conducted to confirm our findings.

Related Articles

Goutam Santosh Panda, Vanita Noronha, Subhash Yadav, Amit Joshi, Vijay Patil, Nandini Menon, Rajiv Kumar, Amit Janu, Abhishek Mahajan, Nilendu Purandare, Jai Prakash Agarwal, George Karimundackal, Kumar Prabhash
Mariana Serrano, Jhajaira M Araujo, Cristian Pacheco, Jackeline Macetas, Mariella A Blum, Alfredo Carrato, Eloy Ruiz, Francisco Berrospi, Carlos Luque, Ivan Chavez, Eduardo Payet, Luis Taxa, Paola Montenegro
Goutam Santosh Panda, Vanita Noronha, Darshit Shah, George John, Anuradha Chougule, Vijay Patil, Rajiv Kumar, Nandini Menon, Ajay Singh, Pratik Chandrani, Abhishek Mahajan, Kumar Prabhash
Beatriz de Jesus Brait, Simone Perpétua da Silva Lima, Franciana Luísa Aguiar, Rafael Fernandes-Ferreira, Camila Ive Ferreira Oliveira-Brancati, Joyce Aparecida Martins Lopes Ferraz, Graciela Domitila Tenani, Marcela Augusta de Souza Pinhel, Leticia Carolina Paraboli Assoni, Augusto Haniu Nakahara, Natalia dos Santos Jábali, Octavio Pennella Fenelon Costa, Maria Eduarda Lopes Baitello, Sidney Pinheiro Júnior, Renato Ferreira Silva, Rita de Cássia Martins Alves Silva, Doroteia Rossi da Silva Souza
Anant Ramaswamy, Sujay Srinivas, Vikram Chaudhari, Prabhat Bhargava, Manish Bhandare, Shailesh V Shrikhande, Vikas Ostwal