ecancermedicalscience

Case Report

Near-complete response to low-dose ceritinib in recurrent infantile inflammatory myofibroblastic tumour

1 Apr 2021
Abhenil Mittal, Aarushi Gupta, Sameer Rastogi, Adarsh Barwad, Swati Sharma

Background: Infantile inflammatory myofibroblastic tumour (IMT) is rare and the majority are driven by anaplastic lymphoma kinase (ALK) rearrangements. Previous literature on the use of ALK inhibitors in paediatric IMTs is extremely limited with no published literature on the use in infants. Crizotinib and ceritinib are two ALK inhibitors which are available and have been used in IMTs; however, ceritinib is much more affordable in the low- and middle-income country (LMIC) setting than crizotinib.

Case: An 11-month-old child, who had undergone surgery for mesenteric IMT at the age of 3 months, had an unresectable recurrence with soft tissue deposits in the subdiaphragmatic location abutting the spleen and paravesical location. As surgery would have entailed splenectomy and partial cystectomy, she was treated with low-dose ceritinib (300 mg/m2/day) with which she had a near-complete response without any toxicity.

Discussion and conclusion: This is the first report of the use of ceritinib at a lower dose for infantile IMT having immense practical applications for the low- and middle-income setting.

Related Articles

Jessica O Esangbedo, Rachael O Oduyemi, Damilare Aduroja, Yetunde O Tola, Olajumoke Dele-Alonge, Emmanuel O Adesuyi, Michael O Ajiboye, Oluwadamilare Akingbade
Badira Cheriyalinkal Parambil, Nirmalya Roy Moulik, Venkata Rama Mohan Gollamudi, Shyam Srinivasan, Chetan Dhamne, Akanksha Chichra, Gaurav Narula, Mukta Ramadwar, Sumeet Gujral, Tanuja Shet, Epari Sridhar, Poonam Panjwani, Uma Sakhadeo, Siddhartha Laskar, Nehal Khanna, Jifmi Jose Manjali, Sajid Qureshi, Vasundhara Patil, Akshay Baheti, Sneha Shah, Kunal Gala, Pappagudi Subramanian, Prashant Tembhare, Nikhil Patkar, Gaurav Chatterjee, Sweta Rajpal, Dhanlaxmi Shetty, Maya Prasad, Girish Chinnaswamy
Olatunde Olaniyi Abiodun Oluwafemi, Eberechukwu Uchime Kasiemobi, Mustapha Babatunde, Bankole Kofi Adedeji, Oyelayo Oluwaseun Olaoluwa, Ismaheel Aderogba Azeez, Ezekpo Okechukwu Obumneme
Chase Peng Yun Ng, Moira Hegyi, Grant Lewison, Tania Pastrana, Eve Namisango, James Cleary, Barbara Hasties, Eric Kabisa, Helena Musau, Kathryn Spangenberg, Paola Ruiz, Zipporah Ali, Mertixell Mallafre-Larrosa, Alfredo Polo, Julie Torode, Ajay Aggarwal, Richard Sullivan, Mevhibe Hocaoglu
Sergine Cindy M Zeufack, Jackton Omoto, Antony Owaya, Everlyn Adoyo, Mercy Rop, Cirillus Ogollah Osongo, Lisa Rahangdale, Craig R Cohen, Chemtai Mungo
Association of Medical and Pediatric Oncologists of Kerala (AMPOK)