ecancermedicalscience

Case Report

Gastrointestinal stromal tumour of the rectum and intestinal obstruction: case report

10 Nov 2020
Ana Karla Uribe Rivera, Andres Guevara Jabiles, Ivan Chavez Passiuri, Elica Garcia Leon, Melvy Guerrero Quiroga, Renier Cruz Baca, Jossue Espinoza Figueroa, Nelson Purizaca Rosillo, Eduardo Payet Meza

We report the case of a 75-year-old female patient with a big tumour in the lower rectum with intestinal obstruction and lower gastrointestinal bleeding history who underwent a tumour biopsy under laparotomy and end colostomy at another hospital in Peru. She came to our institution for clinical evaluation with a pathology result of a rectal gastrointestinal stromal tumour. An extra elevator abdominoperineal resection was performed with tumour-free margins. The histology confirmed a high-grade (G2) rectal gastrointestinal stromal tumour with a mitotic index of 27/50. DOC-1 ( ) and CD117 ( ) in immunohistochemistry. Genomic DNA was extracted from the paraffin-fixed tumour sample, and c.1504_1509dupGCCTAT (p.Ala502_Tyr503dup) mutation was detected in exon 9 of the KIT gene. Imatinib 400 mg per day for 3 years was indicated as adjuvant treatment. Currently, she has a disease-free survival of 12 months.

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