ecancermedicalscience

Case Report

Dealing with pre-existing chronic neutropenia in cancer patients— considerations and consequences in the clinical praxis

29 Oct 2020
Anna-Birgitte Thinggaard, Gabor Liposits, Niels Fristrup

Chronic neutropenia is a rare but important challenge with substantial clinical implications for patients receiving antineoplastic treatment. Treatment-induced neutropenia is a well-known adverse event during chemotherapy and some targeted treatments. Guidelines for administering chemotherapy are rather strict to protect the patient from severe and life-threatening complications. Consequently, patients with chronic neutropenia may receive suboptimal antineoplastic treatment. Autoimmune neutropenia or chronic idiopathic neutropenia (CIN) may affect the antineoplastic treatment by causing delayed drug delivery, dose reductions and early discontinuation of treatment. CIN is characterised by the onset in late childhood or adulthood, affects mostly women, is clinically benign and has rare spontaneous remission. Here, we elucidate the challenges related to chronic neutropenia when administering chemotherapy through two clinical cases. Guidelines may need to be revised in order to optimise the treatment of patients with asymptomatic chronic neutropenia, thus personalising the medical decisions for each patient.

Related Articles

Mauricio Fernandes, Tiago Pugliese Branco, Maria Clara Navarro Fernandez, Carolina Paparelli, Mariana Sarkis Braz, Carolina Sassaki Kishimoto, Helena Maria de Freitas Medeiros, Karen Ebina, Luciana Regina Bertini Cabral, Simone Nagashima, Silvia Amaral de Avó Cortizo, Fabíola Borges, Mariana Ribeiro Monteiro, Ana Beatriz Kinupe Abrahao, Raphael Brandão Moreira, Alze Pereira dos Santos Tavares, Pedro Nazareth Aguiar Jr
Guillermo Valencia-Mesías, Patricia Rioja-Viera, Zaida Morante-Cruz, Yura Toledo-Morote, Silvia Neciosup-Delgado, Henry Gómez-Moreno
Shirin Ahmadnia, Atena Kamel Ghalibaf, Saba Kamkar, Zahra Mohamadzadeh, Mithra Ghalibafian
Hussein H Khachfe, Hamza A Salhab, Mohamad Y Fares, Mohamad A Chahrour, Faek R Jamali