ASCO GU 2026: Updates in bladder cancer

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Published: 17 Mar 2026
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Dr María Natalia Gandur Quiroga - Instituto de Oncología 'Ángel H. Roffo', Universidad de Buenos Aires, Argentina

Dr María Natalia Gandur Quiroga speaks to ecancer about the major breakthroughs in urothelial (bladder) carcinoma.

She says the recent data signals a true turning point in the field, moving beyond incremental progress toward a complete transformation of treatment strategies.

In this expert update, she explores how perioperative care is being redefined, antibody drug conjugates (ADCs) are expanding rapidly, and molecular biomarkers are beginning to guide real clinical decisions.

Neoadjuvant and adjuvant enfortumab vedotin (EV) plus pembrolizumab (pembro) for participants with muscle-invasive bladder cancer (MIBC) who are eligible for cisplatin: Randomized, open-label, phase 3 KEYNOTE-B15 study)
Circulating tumor (ct)DNA-guided adjuvant atezolizumab (atezo) in muscle-invasive bladder cancer (MIBC): Exploratory analysis of ctDNA dynamics in the IMvigor011 trial
Urinary Tumor DNA and ctDNA in Patients with MIBC Who Received Perioperative Durvalumab in NIAGARA
RC48G001: A phase 2 study of disitamab vedotin in HER2-expressing previously treated advanced UC
KEYMAKER-U04 Substudy 04B: First-Line Enfortumab Vedotin + Pembrolizumab-Based Immune Checkpoint Inhibitor Combinations for Advanced Urothelial Carcinoma
Gemcitabine intravesical system (Gem-iDRS) in combination with cetrelimab (CET) versus chemoradiotherapy (CRT) in muscle-invasive bladder cancer (MIBC): SunRISe-2 final results