ecancermedicalscience

Case Report

A case of Warthin-like papillary thyroid carcinoma with diffuse sclerosing stroma and a novel RET mutation: a new entity or a combined tumour?

2 Oct 2019
Fausto Maffini, Daniele Lorenzini, Daniela Lepanto, Elvio De Fiori, Caterina Fumagalli, Alessandra Rappa, Marta Tagliabue, Massimo Barberis

Activating mutations of the RET gene have been described for both papillary (chromosomal rearrangement) and medullary (missense mutations) thyroid carcinomas. Here, we describe a case of a Warthin-like variant of papillary thyroid carcinoma displaying some morphological aspects that mimic the diffuse sclerosing variant. The tumour harboured BRAF V600E mutation and a novel germline point mutation in the RET gene, with unknown clinical and pathological meaning.

Article metrics: 447 views
257
190

Related Articles

Patricia Rioja, Guillermo Valencia, César Centurión-Rodriguez, Zaida Morante, Mercedes Bravo, Lourdes Huanca, Carlos Morante
Paul Summers, Giulia Saia, Alberto Colombo, Paola Pricolo, Fabio Zugni, Sarah Alessi, Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Massimo Bellomi, Giuseppe Petralia
Luca Nicosia, Antuono Latronico, Mariagiorgia Farina, Anna Carla Bozzini, Paola Baratella, Viviana Enrica Galimberti, Stefano Fiori, Marta Montesano, Enrico Cassano
Milena Perez Mak, Fatima Solange Pasini, Lixia Diao, Fabyane O Teixeira Garcia, Tiago Kenji Takahashi, Denyei Nakazoto, Renata Eiras Martins, Cristiane Maria Almeida, Marco Aurelio Vamondes Kulcsar, Valdelania Aparecida Lamounier, Emily Montosa Nunes, Isabela Cristina de Souza, Marcio Ricardo Taveira Garcia, Alex Vieira Amadio, Sheila Aparecida C Siqueira, Igor Moysés Longo Snitcovsky, Laura Sichero, Jing Wang, Gilberto de Castro Jr
Maria Asunción Algarra, Maria José Juan Fita, Sergio Sandiego, Héctor Augusto Aguilar, Pablo Álvarez, Mateo Quispe, Antonio Salvador, Adoración Egido, Javier Lavernia, Isidro Machado, José Rubio Briones, Miguel Ángel Climent