ecancermedicalscience

Review

Challenges and shifting paradigms in clinical trials in oncology, the case for immunological and targeted therapies

5 Jul 2019
Diana Carolina Sotelo-Rodríguez, Alejandro Ruíz-Patiño, Luisa Ricaurte, Oscar Arrieta, Zyanya Lucia Zatarain-Barrón, Andrés F Cardona

The advent of immunotherapy has undoubtedly changed the current standard for cancer treatment. Immunotherapy offers the possibility of achieving excellent results—a new alternative for patients with advanced-stage or relapsed disease. Nowadays, the progress made in tumour biology has led to multiple advances in clinical and translational cancer research. Many oncogenic pathways responsible for tumour growth and metastases have been described and, consequently, multiple new cancer therapeutic agents have been developed and are under current investigation. Due to this rapid increase in knowledge and pharmaceutical development, traditional clinical trials designs have encountered major limitations. The pharmacological differences (in toxicity profiles and effectiveness patterns) between immunotherapy and chemotherapy have caused traditional clinical trials to evolve in order to meet this emerging need. This review focuses on the different options pertaining to clinical trial design that have arisen in the field of immuno-oncology, as well as the challenges of accurately interpreting traditional survival analyses within this novel area of cancer medicine.

Related Articles

Arun Sankar Sudha, Ravikumar Rejnish Kumar, Milan Anjanappa, Cessal Thomas Kainickal, Aleyamma Mathew, Ramadas Kunnambath
Maria Alice Franzoi, Marion Procter, Chris Twelves, Noam Pondé, Daniel Eiger, Orianne Emond, Emma Clark, Damien Parlier, Sébastien Guillaume, Linda Reaby, Evandro de Azambuja, Jose Bines
Rahat Ul-Ain, Mahwish Faizan, Saadia Anwar, Shazia Riaz, Alia Ahmad, Huma Zafar, Wasila Shamim
Elvis Anyaehiechukwu Okolie, David Aluga, Seun Anjorin, Felicity Nneoma Ike, Ekene Moses Ani, Blessing Ifeoma Nwadike
Aditya Dhanawat, Vanita Noronha, Anant Ramaswamy, Shreya Gattani, Renita Castelino, Ratan Dhekale, Sarika Mahajan, Vijay Patil, Nandini Menon, Anuradha Daptardar, Vikram Gota, Shripad Banavali, Rajendra Badwe, Kumar Prabhash