ecancermedicalscience

Special Issue

The role of human papillomaviruses in carcinogenesis

29 Apr 2015
Raffaella Ghittoni, Rosita Accardi, Susanna Chiocca, Massimo Tommasino

The human papillomavirus (HPV) family comprises more than 170 different types that preferentially infect the mucosa of the genitals, upper-respiratory tract, or the skin. The ‘high-risk HPV type’, a sub-group of mucosal HPVs, is the cause of approximately 5% of all human cancers, which corresponds to one-third of all virus-induced tumours. Within the high-risk group, HPV16 is the most oncogenic type, being responsible for approximatively 50% of all worldwide cervical cancers. Many studies suggest that, in addition to the high-risk mucosal HPV types, certain cutaneous HPVs also have a role in the development of non-melanoma skin cancer (NMSC).

Functional studies on the HPV early gene products showed that E6 and E7 play a key role in carcinogenesis. These two proteins use multiple mechanisms to evade host immune surveillance, allowing viral persistence, and to deregulate cell cycle and apoptosis control, thus facilitating the accumulation of DNA damage and ultimately cellular transformation.

The demonstration that high-risk HPV types are the etiological agents of cervical cancer allowed the implementation in the clinical routine of novel screening strategies for cervical lesions, as well as the development of a very efficient prophylactic vaccine. Because of these remarkable achievements, there is no doubt that in the coming decades we will witness a dramatic reduction of cervical cancer incidence
worldwide.

Related Articles

Natalia Godoy-Casasbuenas, Fabian Gil, Nelson Arias, Claudia Uribe Pérez, Harold Mauricio Casas Cruz, Luisa Bravo Goyes, Esther de Vries
Sivaranjini Kannusamy, Amey Oak, Sandhya Cheulkar, Kamesh Maske, Esha Dashmukhe, Ashwini Patil, Manisha Morajkar, Manju Sengar, Ganesh Balasubramaniam, Rajesh Dikshit
Asma’u Usman, Shamsu Sahalu Bello, Aisha Abdurrahman, Fatima Abubakar Rasheed, Shuaibu Adam, Abubakar Dahiru
Denisse Castro, Brady Beltrán, Oscar Carnero, Mauricio Póstigo, Wilhelm Valdivia, Cinthia Figueroa, Manuel Leiva, Marco López, Virgilio E Failoc-Rojas
Priyal Chakravarti, Kamalesh Kumar Patel, Atul Budukh, Divya Khanna, Pankaj Chaturvedi, Satyajit Pradhan, Rajesh Dikshit, Rajendra Badwe