In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.
ecancermedicalscience
Research
Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
22 Apr 2015
- Categories:
- Head & neck
- Global health & cancer
- Low-middle income
