ecancermedicalscience

Research

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

22 Apr 2015
Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Related Articles

Groesbeck Preer Parham, Kabongo Mukuta Mathieu, Tankoy Gombo YouYou, Michael L Hicks, Ronda Henry-Tillman, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Leeya Pinder, Maya M Hicks, Louis Kanda, Mirielle Kanda
Michael L Hicks, Alex Mutombo, Tankoy Gombo YouYou, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Kabongo Mukuta Mathieu, Ronda Henry-Tillman, Dorothy Lombe, Maya M Hicks, Leeya Pinder, Louis Kanda, Mirielle Kanda, Groesbeck P Parham
Kabongo Mukuta Mathieu, Tankoy Gombo YouYou, Michael L Hicks, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Leeya Pinder, Maya M Hicks, Louis Kanda, Mirielle Kanda, Groesbeck P Parham, Ronda Henry-Tillman
Tankoy Gombo YouYou, Kabongo Mukuta Mathieu, Michael L Hicks, Ronda Henry-Tillman, Alex Mutombo, Mukanya Mpalata Anaclet, Mulumba Kapuku Sylvain, Maya M Hicks, Leeya Pinder, Louis Kanda, Mirielle Kanda, Groesbeck P Parham
Mauricio Fernandes, Tiago Pugliese Branco, Maria Clara Navarro Fernandez, Carolina Paparelli, Mariana Sarkis Braz, Carolina Sassaki Kishimoto, Helena Maria de Freitas Medeiros, Karen Ebina, Luciana Regina Bertini Cabral, Simone Nagashima, Silvia Amaral de Avó Cortizo, Fabíola Borges, Mariana Ribeiro Monteiro, Ana Beatriz Kinupe Abrahao, Raphael Brandão Moreira, Alze Pereira dos Santos Tavares, Pedro Nazareth Aguiar Jr
Ranjeeta Subedi, Atul Budukh, Sandhya Chapagain, Pradip Gyanwali, Bishal Gyawali, Kopila Khadka, Chanda Thakur, Uma Dahal, Rajesh Dikshit, Anjani Kumar Jha, Meghnath Dhimal