Supporting oncology professionals through education

The content on this site is intended for healthcare professionals only

ecancermedicalscience

Submit article
Articles
Editorials
Special issues
Author interviews
https://doi.org/10.3332/ecancer.2015.525
Abstract | Full Article | PDF

Research

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

22 Apr 2015
Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Related Articles

1969-a-rare-case-of-clear-cell-hidradenocarcinoma-presenting-with-recurrent-pleural-and-cardiac-effusion
Camilla Engelsmann, Gitte Wooler, Vladimira Horvat, Shailesh Balasaheb Kolekar
1970-a-prospective-cohort-study-of-the-incidence-etiology-and-outcome-of-pneumonia-among-cancer-patients-in-an-oncology-intensive-care-unit-from-eastern-india
Simran Malik, Sudipta Mukherjee, Pralay Shankar Ghosh, Santanu Bagchi, Gaurav Goel, Soumyadip Chatterji, Saugata Sen, Debashree Guha Adhya, Sangeeta Das Bhattacharya, Sanjay Bhattacharya
1965-sociodemographic-factors-and-treatment-effects-on-quality-of-life-in-locally-advanced-breast-cancer-a-cross-sectional-study
Sasongko Hadi Priyono, Winardi Budiwinata, Budianto Tedjowitono, Effendy, Muhamad Daffa Ibnurasy Pratama
1966-real-world-outcomes-with-tepotinib-in-a-series-of-indian-patients-with-met-exon-14-skipping-positive-non-small-cell-lung-cancer
Rohini Sebastian, Josh Thomas Georgy, Arun George, Prisca Santhanam, Raiza Philip, Anjana Joel, Ajoy Oommen John, Deepa Susan Joy Philip, Divya Bala Thumaty, Thomas Alex Kodiatte, Ashish Singh, Rekha Pai
1959-vanishing-clear-cell-carcinoma-of-the-kidney-presenting-with-skin-metastases-a-case-report
Sidhart Misra, Zainab Yusufali Motiwala, Ayyaz Mulla, Jagatheswaran Chinnathambi, Danny Darlington Carbin
1960-clinical-outcomes-of-patients-with-advanced-egfr-mutated-nonsquamous-cell-lung-carcinoma-treated-at-a-tertiary-care-hospital
Faiza Ahmed, Aqsa Amjad, Eman Anwar, Mohammad Saad Saleem Naviwala, Warda Saleem, Nawazish Zehra, Munira Moosajee, Yasmin Abdul Rashid

More from ecancer

Register with ecancer to receive our newsletter

Register here

Explore patient resources at ecancerpatient

Visit site

Find out more about ecancer and the work we do

About ecancer

Support ecancer's work by making a donation