ecancermedicalscience

Case Report

Uterine leiomyosarcoma with central nervous system metastases

5 Mar 2015
Carina Meira Abrahão, Fernando Cotait Maluf

Leiomyosarcoma (LMS) is a rare tumour and comprises 2–3% of all malignant uterus neoplasms [1]. Leiomyosarcoma is characterised by aggressive behaviour, high recurrence rates, and poor overall survival, despite multimodal treatment [3]. Surgery is the main treatment and consists of total abdominal hysterectomy. A randomised trial consisting of 224 patients diagnosed with uterine sarcomas stage I and II showed that adjuvant radiotherapy improves locoregional control. The role of adjuvant chemotherapy is still unclear [1]. Unfortunately, roughly 50% of patients with organ-confined disease will usually develop distant metastasis to lung, peritoneum, liver, pelvic, and para-aortic lymph nodes. Brain metastases are extremely rare [5].

Related Articles

Saran Green, Aida Santaolalla, Beth Russell, Gincy George, Harriet Wylie, Maria Monroy-Iglesias, Ailbhe Lawlor, Mark Minott, Annette Carty, Vernon Bailey, Tene Green, Zhane Peterson, Charlene Young, Mieke Van Hemelrijck
Chinelo C Nduka, Chizobam A Nweke, Runcie C W Chidebe, Candidus Nwakasi
Chinomso Ugochukwu Nwozichi, Omolabake Salako, Anita Frimpomaa Oppong, Margaret Olutosin Ojewale
Anass Baladi, Hassan Abdelilah Tafenzi, Fatim-Zahra Megzar, Ibrahima Kalil Cisse, Othmane Zouiten, Leila Afani, Ismail Essaadi, Mohammed El Fadli, Rhizlane Belbaraka