A survey was conducted to identify perceptions of cancer and its treatment among the general public, patients, and care givers in six countries. The purpose of the research—the PACE Cancer Perceptions Index (2012)—was to share public perspective on the progress of cancer care and treatment with stakeholders who make decisions about cancer innovation and access to treatments in order to allow patient-centric decisions. The results revealed that although understanding of cancer is increasing, a number of misconceptions persist. Although most respondents recognise that progress has been made in cancer treatment and a majority express satisfaction with this progress, they nevertheless want more investment and faster access to new cancer treatments. In particular, there was clear agreement that more collaboration was needed across countries and between the various stakeholders within countries. In addition, a clear majority of respondents does not think that their country invests sufficient funds in cancer research, and there is concern that progress may be jeopardised by the current difficult economic times.