According to a 2020 report, the World Health Organization explained how, in 20 years, the prevalence of cancer cases will increase by 60% worldwide. In lower-middle-income countries, this figure will be 74.07%. Therefore, the authors propose a series of recommendations, such as how to address both traditional health indicators and the psychosocial environment, to improve the health system. The objective of this study is to demonstrate the impact of cancer on the quality of life (QoL) and health status of oncology patients in Colombia. An observational cross-sectional study using patient reported outcomes tools, such as European Organization for Research and Treatment of Cancer (EORTC) Quality of Life of Cancer Patients (QLQ-C30) and EuroQoL-5 dimensions questionnaire-3 levels (EQ5D-3L), was carried out. The information of 356 people was compiled. They were contacted by patient associations. The results were analysed using descriptive and inferential statistics, using ordinary least squares methodology. For the EORTC QLQ-C30, overall health status was 66.05 (95% confidence interval: 63.78–68.32), on the functional scales, emotional and social function were the two scales with the lowest ratings (71.57 and 71.77), without any representative differences. For the EQ5D-3L, the average utility was 0.70 (Standard deviation: 0.20); 50% of people had a utility between 0.63 and 0.82. The analysed population was most affected in the following areas: financial difficulties, insomnia, anxiety, depression and emotional functioning, establishing the need for future interventions and the creation of public policies that generate a better QoL for patients.