ecancermedicalscience

Review

Looking beyond the smokescreen: can the oral microbiome be a tool or target in the management of tobacco-associated oral cancer?

1 Feb 2021
Snehal Kadam, Madhusoodhanan Vandana, Sudhanshu Patwardhan, Karishma S Kaushik

A wide range of microbes inhabit the oral cavity, and bacterial and fungal communities most often exist as structured communities or biofilms. The use of tobacco alters the structure of the oral microbiome, including that of potentially malignant lesions, and the altered oral microbiome influences key microenvironmental changes such as chronic inflammation, secretion of carcinogenic toxins, cellular and tissue remodelling and suppression of apoptosis. Given this, it is clear that the bacterial and fungal biofilms in potentially malignant states are likely not passive entities, but could play a critical role in shaping potential malignant and carcinogenic conditions. This holds potential towards leveraging the oral microbiome for the management of tobacco-associated potentially malignant lesions and oral cancer. Here, we explore this line of investigation by reviewing the effects of tobacco in shaping the oral microbiome, and analyse the available evidence in the light of the microbiome of oral potentially malignant and cancerous lesions, and the role of dysbiosis in carcinogenesis. Finally, we discuss possible interventions and approaches using which the oral microbiome could be leveraged towards precision-based oral cancer therapeutics.

Related Articles

Lawrence Kofi Acheampong, Kofi Effah, Joseph Emmanuel Amuah, Ethel Tekpor, Comfort Mawusi Wormenor, Isaac Gedzah, Seyram Kemawor, Ateba Cynthia Kachana, Peace Afi Danso, Nana Owusu Mensah Essel, Mabel Asomaning, Dominic Agyiri, Patrick Kafui Akakpo
Severyn Ferneza, Markiyan Fetsych, Roman Shuliak, Halyna Makukh, Natalia Volodko, Roman Yarema, Tara Fetsych
Eduardo Payet, Joan Perez, Gustavo Sarria, Silvia Neciosup, Francisco Berrospi, Sheila Vilchez, Jorge Dunstan, Ronald Perez, Mauricio Vassallo, Santiago Salgado, Nanto Caparachín, Joseph A Pinto, Alexis Holguin
Namrata Mathew, Anjana Joel, Anand George Andrews, Ajoy Oommen John, Ashish Singh
Chandrayee Sarker, Vivek S Radhakrishnan, Paya Mandal, Jeevan Kumar, Saurabh Bhave, Rimpa Achari, Debdeep Dey, Indu Arun, Zameer Latif, Neeraj Arora, Deepak Mishra, Mammen Chandy, Reena Nair
Chemtai Mungo, Emily Barker, Magdalene Randa, Jeniffer Ambaka, Cirilus Ogollah Osongo