Short Communication

A randomised trial evaluating Bevacizumab as adjuvant therapy following resection of AJCC stage IIB, IIC and III cutaneous melanoma: an update

12 Nov 2008
S Biswas, J Wrigley, C East, A Hern, A Marshall, J Dunn, P Lorigan, M Middleton, P Corrie

At present, there are no standard therapies for the adjuvant treatment of malignant melanoma. Patients with primary tumours with a high-Breslow thickness (stages IIB and IIC) or with resected loco-regional nodal disease (stage III) are at high risk of developing metastasis and subsequent disease-related death. Given this, it is important that novel therapies are investigated in the adjuvant melanoma setting. Since angiogenesis is essential for primary tumour growth and the development of metastasis, anti-angiogenic agents are attractive potential therapeutic candidates for clinical trials in the adjuvant setting. Therefore, we initiated a phase II trial in resected high-risk cutaneous melanoma, assessing the efficacy of bevacizumab versus observation.

In the interim safety data analysis, we demonstrate that bevacizumab is a safe therapy in the adjuvant melanoma setting with no apparent increase in the surgical complication rate after either primary tumour resection and/or loco-regional lymphadenectomy.

Article metrics: 639 views

Related Articles

Nkechi Anne Enechukwu, Gabriel Olabiyi Ogun, Ogochukwu Ifeanyi Ezejiofor, Titus Osita Chukwuanukwu, Joseph Yaria, Adekunle Olufemi George, Adebola Olufunmilayo Ogunbiyi
Małgorzata Sawicka-Żukowska, Włodzimierz Łuczyński, Jakub Dobroch, Maryna Krawczuk-Rybak