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Abstract | Full HTML Article | PDF ecancer 12 836 / https://doi.org/10.3332/ecancer.2018.836

Case Report

Cryptococcal meningoencephalitis in patients with mantle cell lymphoma on ibrutinib

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, has been increasingly widely used in relapsed and refractory mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia [1, 2]. With its use becoming more common, there have been emerging case reports of opportunistic infections like cryptococcal infections [3–8]. These infections in patients receiving ibrutinib were mostly reported in patients with chronic lymphocytic leukaemia, who have poor immune reconstitution. Here, we report two cases of cryptococcal meningoencephalitis in patients with MCL on ibrutinib.

Keywords: Cryptococcal Meningoencephalitis, Mental cell lymphoma, ibrutinib

Categories:

Haematology oncology

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European Cancer Organisation European Institute of Oncology

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ecancer Global Foundation