Background: Breast cancer (BC) represents a major public health issue in Morocco. This study aims to describe the epidemiological, clinical and histopathological profile of women with BC diagnosed at the Taza Reproductive Health Reference Center in eastern Morocco between November 2016 and December 2024.

Methods: This was a descriptive, retrospective, cross-sectional study of 412 confirmed cases of BC. Data were collected from archived medical records and analysed using IBM SPSS Statistics software.

Results: 412 new cases were identified, with an increasing trend over the years, from 15.1 per 100,000 in 2017 to 29.2 per 100,000 in 2024. The mean age at diagnosis was 51.5 ± 11.8 years. The majority of patients (59%) were aged between 40 and 59, 70.9% were married and 52.6% lived in rural areas. Most were housewives (97.3%). Regarding health coverage, 73.5% were insured, including 40.3% affiliated with RAMED’s health insurance regime. Clinically, the left breast was affected in 54.1% of cases and the predominant tumour localisation was the superolateral quadrant (57.8%). The most frequent histological type was invasive ductal carcinoma (95%). According to Scarff–Bloom–Richardson (SBR) histoprognostic grade, 68% of tumours were grade II, 28% grade III and 4% grade I.

Conclusion: This study highlights a progressive increase in the incidence of SBR in the Taza region, as well as a socio-economic profile marked by precariousness and rurality. Intermediate-grade infiltrating ductal carcinoma is the dominant histological form. These results underline the importance of early detection and improved access to care, particularly in rural areas.