New target identified for squamous cell lung cancer

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Published: 15 Apr 2011
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Prof Matthew Meyerson - Dana Farber Cancer Institute, Boston, United States
Scientists at the Dana Farber Cancer Institute have identified a mutation in the DDR2 gene that may indicate which patients with squamous cell lung cancer will respond to dasatinib. Using standard genetic sequencing techniques, Prof Meyerson and colleagues identified mutations in the DDR2 kinase gene in about 3 percent of squamous cell lung cancers and cell lines. Furthermore, they found that tumour cells with these DDR2 mutations responded to treatment with dasatinib.