Preventing metastases by tackling exosomes

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Published: 19 Dec 2013
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Dr Jeff Wrana - University of Toronto, Canada

Dr Wrana talks to ecancer at SABCS 2013 about his work looking at exosomes - cell derived vescicles - which affect how cancer cells become mobile, in turn causing cancer metastases.

The fibreblast stimulating mobility of tumour cells was examined and exosomes were found to be the main carrier of the signal for movement.

This movement signal, known as the 'planar cell polarity signal', has been found to be the main signal involved in the process. If interfered with there is the potential to stop cell mobility and thus metastases; as shown in animal models so far.