ctDNA testing improves detection of treatable metastases compared to standard care in colorectal cancer

Share :
Published: 8 Oct 2025
Views: 127
Rating:
Save
Dr Arvind Dasari - MD Anderson Cancer Center, Houston, USA

Dr Arvind Dasari speaks to ecancer about the clinical utility of including circulating tumour DNA (ctDNA) monitoring in standard of care colorectal cancer surveillance.

Dr Dasari explores new findings showing how circulating tumour DNA (ctDNA) testing can transform colorectal cancer follow-up after surgery. He says that detecting oligometastatic disease (OMD) is key to offering curative metastasis-directed therapy (MDT).

The results form this trial show that ctDNA testing detects recurrence and treatable metastases far better than standard methods. ctDNA-positive patients are much more likely to receive potentially curative MDT. 

Dr Dasari highlights that future CRC follow-up should consider personalised surveillance based on ctDNA results.

Related Videos

Aspirin in stage III colorectal cancer shows no significant DFS benefit but favourable safety

Dr Atsuo Takashima - National Cancer Center Hospital, Tokyo, Japan
Aspirin in stage III colorectal cancer shows no significant DFS benefit but favourable safety ( Dr Atsuo Takashima - National Cancer Center Hospital, Tokyo, Japan )
1 Jun 2026

ASCO 2026: Latest updates in mRCC

Dr Toni Choueiri, Prof Viktor Grünwald, Dr Martin Voss and Prof Jens Bedke
ASCO 2026: Latest updates in mRCC ( Dr Toni Choueiri, Prof Viktor Grünwald, Dr Martin Voss and Prof Jens Bedke )
30 May 2026

Phase I/II trial shows promising activity of invikafusp alfa in PD-1–resistant GI cancers

Dr Elena Élez - Vall d'Hebron Institute of Oncology, Barcelona, Spain
Phase I/II trial shows promising activity of invikafusp alfa in PD-1–resistant GI cancers ( Dr Elena Élez - Vall d'Hebron Institute of Oncology, Barcelona, Spain )
18 Aug 2025

ctDNA evaluation may play a prognostic role in stage III colon cancer treated with celecoxib

Dr Jonathan Andrew Nowak - Dana-Farber Cancer Institute, Boston, USA
ctDNA evaluation may play a prognostic role in stage III colon cancer treated with celecoxib ( Dr Jonathan Andrew Nowak - Dana-Farber Cancer Institute, Boston, USA )
26 Feb 2025

Addition of trastuzumab to chemo does not provide significant survival benefit in HER-2 positive stomach cancer

Dr Anna Dorothea Wagner - Lausanne University Hospital, Lausanne, Switzerland
Addition of trastuzumab to chemo does not provide significant survival benefit in HER-2 positive stomach cancer ( Dr Anna Dorothea Wagner - Lausanne University Hospital, Lausanne, Switzerland )
21 Feb 2025

Nivolumab plus ipilimumab shows superior efficacy in metastatic colorectal compared to nivolumab monotherapy

Dr Thierry Andre - Sorbonne Université and Saint Antoine Hospital, Paris, France
Nivolumab plus ipilimumab shows superior efficacy in metastatic colorectal compared to nivolumab monotherapy ( Dr Thierry Andre - Sorbonne Université and Saint Antoine Hospital, Paris, France )
13 Feb 2025

Revolutionising myeloma treatment through immune profiling

Dr Romanos Sklavenitis-Pistofidis - Dana-Farber Cancer Institute, Boston, USA
Revolutionising myeloma treatment through immune profiling ( Dr Romanos Sklavenitis-Pistofidis - Dana-Farber Cancer Institute, Boston, USA )
28 Oct 2024

ESMO 2024: Optimising the personalisation of prostate cancer treatment

Prof Alison Birtle, Dr Alejo Rodríguez-Vida, Dr Pasquale Rescigno and Prof Gunhild von Amsberg
ESMO 2024: Optimising the personalisation of prostate cancer treatment ( Prof Alison Birtle, Dr Alejo Rodríguez-Vida, Dr Pasquale Rescigno and Prof Gunhild von Amsberg )
15 Sep 2024

Trifluridine/tipiracil followed by regorafenib can be an effective treatment sequence in pretreated mCRC

Prof Michel Ducreux - Gustave Roussy Cancer Centre, Paris, France
Trifluridine/tipiracil followed by regorafenib can be an effective treatment sequence in pretreated mCRC ( Prof Michel Ducreux - Gustave Roussy Cancer Centre, Paris, France )
24 Jul 2024