Dr Panagiotis Vlachostergios speaks to ecancer about the association between tumour KIM-1 gene (HAVCR1) expression and immune infiltrates in renal cell carcinoma.

KIM-1 is a protein linked to kidney cancer that may help predict immunotherapy outcomes. Research focuses on its expression and its relationship with immune cell types in clear-cell renal cell carcinoma patients.

Data from 533 patients shows that KIM-1 expression correlates positively with CD8 and CD4 T cells and negatively with T regulatory cells.

The HAVCR1 gene, which encodes KIM-1, also correlates with immune markers like PD-L1 and CTLA-4, indicating a potential immune regulatory role.