ecancermedicalscience

Review

The role of surgery in advanced epithelial ovarian cancer

17 Aug 2016
María Martín-Cameán, Elsa Delgado-Sánchez, Antonio Piñera, Maria Dolores Diestro, Javier De Santiago, Ignacio Zapardiel

Nowadays, the standard management of advanced epithelial ovarian cancer is correct surgical staging and optimal tumour cytoreduction followed by platinum and taxane-based chemotherapy. Standard surgical staging consists of peritoneal washings, total hysterectomy, and bilateral salpingo-oophorectomy, inspection of all abdominal organs and the peritoneal surface, biopsies of suspicious areas or randomised
biopsies if they are not present, omentectomy and para-aortic lymphadenectomy. After this complete surgical staging, the International Federation of Gynaecology and Obstetrics (FIGO) staging system for ovarian cancer is applied to determine the management and prognosis of the patient. Complete tumour cytoreduction has shown an improvement in survival. There are some criteria to predict cytoreduction
outcomes based on serum biomarkers levels, preoperative imaging techniques, and laparoscopic-based scores. Optimised patient selection for primary cytoreduction would determine patients who could benefit from an optimal cytoreduction and might benefit from interval surgery. The administration of intraperitoneal chemotherapy after debulking surgery has shown an increase in progression-free survival and overall survival, especially in patients with no residual disease after surgery. It is considered that 3–17% of all epithelial ovarian carcinoma (EOC) occur in young women that have not fulfilled their reproductive desires. In these patients, fertility-sparing surgery is a worthy option in early ovarian cancer.

Related Articles

Matías A Atencio, Elías J Ortega Chahla, Mirko Vidic, Candela V Giuffré, Mickaela Echavarría Demichelis, Joaquín A Luini, Franco E Espinoza, Ana M Rosas, María Cruz Germain, Abril Montani, Iñaki M Dopazo Danieli, Joel A Schernenco, Lucas G Durán, María E Esandi
Ashutosh Mishra, Amit Kumar, Ajay Gogia, Chinmay Bagla, Gajendra Pandit, Jyoti Sharma, Jyoutishman Saikia, Rohan Kapoor, D N Sharma, Atul Batra, Surendra Saini, Supriya Mallick, Nishkarsh Gupta, Brajesh Ratre, Ruchi Rathore, Sandeep Mathur, Sunil Kumar, Suryanarayana Deo
Patricia N Apenteng, Larry Akoko, Vihar Kotecha, Theresia Mwakyembe, Masumbuko Mwashambwa, Rukia Himid, Deo Hando, Charles Komba, Ally Mwanga, Peter Mbele, Paul Itule, Joshua Jackson, Mungeni Misidai, Cameron Gaskill, Doruk Ozgediz, Nathan Brand
Moushumi Suryavanshi, Prashant Mehta, Manoj Kumar, Saphalta Bhagmar, Vidit Kapoor, Dushyant Kumar, Sweta Mishra, Bhawna Chauhan