ecancermedicalscience

Review

Cancer-associated thrombotic microangiopathy

28 Jun 2016
K Govind Babu, Gita R Bhat

Cancer-associated thrombotic microangiopathy refers to a group of disorders characterised by microvascular thrombosis, thrombocytopenia, and ischaemic end-organ damage. Haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura are the two major subtypes. It can be a manifestation of the malignancy itself or a complication of its therapy. The addition of several new drugs to the therapeutic armamentarium of cancer has brought to light several novel causative factors of this hitherto uncommon complication. This review covers the aetiology, pathogenesis, clinical manifestations, complications, and the management of cancer-associated thrombotic microangiopathy. Careful review of the patient’s medical records coupled with the correlation of clinical findings and laboratory reports can help clinch the diagnosis and institute appropriate treatment on time.

Related Articles

Kamboji Sharanya, Lulu Abdul khader, Fathima Shahama Oliyath Vazhayil, Ghazal Tansir, Vaishnavi Vishwas, Simran Kaur, Sameer Rastogi, Ratna Sharma
Abhijit Shah, Surag KR, Anupam Choudhary, Kasi Viswanath, Krishnakanth AVB, Chaitanya Krishna, Padmaraj Hegde, Gayathri S, Swathi PM
Priti Singh, Chaithanya Leon, Simran Kaur, Atul Batra, Prashant Tayade, Muthukrishnan Suriya Prakash, Ratna Sharma