ecancermedicalscience

Clinical Study

Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent

15 Apr 2015
Pan Pantziarka, Vidula Sukhatme, Gauthier Bouche, Lydie Meheus, Vikas P Sukhatme

Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. There is evidence that at the clinically relevant doses, itraconazole has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. The evidence for these anticancer effects, in vitro, in vivo, and clinical are summarised, and the putative mechanisms of their action outlined. Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. Given the evidence presented, a case is made that itraconazole warrants further clinical investigation as an anti-cancer agent. Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper.

Related Articles

Sanjit Kumar Agrawal, Vishal Kewlani, Noopur Priya, Abhishek Sharma, Joydeep Ghosh, Sanjoy Chatterjee, Rosina Ahmed
Agustin Buero, Walter S Nardi, Domingo J Chimondeguy, Leonardo G Pankl, Gustavo A Lyons, David Gonzalez Arboit, Sergio D Quildrian
Amit Joshi, Vijay Maruti Patil, Vanita Noronha, Atanu Bhattacharjee, Nandini Menon, Amit Kumar, Parmanand Jain, Sadaf Mukadam, Avadhoot Shrinivas, Anjali Punia, Anuja Abhyankar, Amit Agarwal, Satvik Khaddar, Anu Rajpurohit, Kanteti Aditya Pavan Kumar, Rahul Ravind, Kishore Das, Vikas Talreja, Sachin Dhumal, Kumar Prabhash
Jemma Arakelyan, Alisa Movsisyan, Lilit Sargsyan, Armine Chopikyan, Diana Andreasyan, Arevik Torosyan, Ruzanna Papyan, Hovhannes Vardevanyan, Samvel Bardakhchyan, Artashes Tadevosyan, Gevorg Tamamyan, Armen Tananyan, Samvel Danielyan, Dickran Kazandjian
Deepthi Valiyaveettil, Swapna Jilla, Jonnalagadda Mohan Krishna, Raja Kollu, Chandrasekhar Patil, Ranadheer Gupta
Vilma Adriana Tripodoro, Victoria Llanos, María Laura Daud, Pilar Muñoz, Eden Del Mar, Romina Tranier, Sol Sandjian, Silvina De Lellis, Juan Manuel Días, Alvaro Saurí, Gustavo Gabriel De Simone, Xavier Gómez-Batiste