ecancermedicalscience

Case Report

Syndrome of inappropriate anti-diuretic hormone in non-small cell lung carcinoma: a case report

14 Nov 2012
Philip McDonald, Colleen Lane, Graciela E Rojas, Ashiq Masood

Paraneoplastic syndrome (PNS) related to lung cancer is very common. However, the syndrome of inappropriate anti-diuretic hormone secretion (SIADH) is rare in non-small cell lung cancer (NSCLC). We are reporting the case of a 58-year-old female presenting with dyspnea, cough, weight loss, digital clubbing, and one week of haemoptysis. CT showed a mediastinal mass completely encasing her
superior vena cava, causing significant narrowing of the trachea and right mainstem bronchus. Bronchoscopy and biopsy identified a nonresectable NSCLC. Palliative radiation therapy was initiated. The day after her first radiation treatment, the patient developed asymptomatic hyponatremia, confirmed to be SIADH by laboratory evaluation. NSCLC-associated SIADH has been reported only thrice over the past two decades and never following radiation therapy with clinical improvement. The patient was discharged home on fluid restriction after her respiratory status improved to continue outpatient radiation and chemotherapy. SIADH in the setting of NSCLC is discussed.

Related Articles

Jéssica Silva Nicolau, Rossana Veronica Mendoza Lopez, Carolina Terra de Moraes Luizaga, Karina Braga Ribeiro, Rosimeire Aparecida Roela, Simone Maistro, Maria Lucia Hirata Katayama, Renato José Mendonça Natalino, Gilberto de Castro Jr, Jose Eluf Neto, Maria Aparecida Azevedo Koike Folgueira
Akhil Kapoor, Vanita Noronha, Amit Joshi, Vijay M Patil, Nandini Menon, Rajesh Bollam, Vikas Talreja, Supriya Goud, Sucheta More, Leena Solanki, Srushti Shah, Anuradha Chougule, Abhishek Mahajan, Kumar Prabhash
Yazmín A Ramírez-Galván, Servando Cardona-Huerta, Guillermo Elizondo-Riojas, Alberto Montemayor-Martínez, Jesús I Morales-Escajeda, Carlos E Herrera-Peña
Aragaw Tesfaw, Hanna Berihun, Eshetie Molla, Gashaw Mihret, Dejen Getaneh Feleke, Ermias Sisay Chanie, Biruk Demissie, Tewodros Yosef, Abel Shita, Fitalew Tadele, Efrem Fenta
Agustin Buero, Domingo J Chimondeguy, Rodolfo Auvieux, Gustavo A Lyons, Leonardo G Pankl, Guillermo Puchulo, Silvia Quadrelli