ecancermedicalscience

Case Report

BRCA mutation and multiple primary malignancies: a rare case of recurring triple-negative breast cancer and cervical cancer

2 Jul 2025
Naciri Meryem, Aouzah Fatima Ezzahra, El Ghanmi Adil, Ghazi Bouchra Fichtali Karima Sqalli Houssaini Mohammed, Kouhen Fadila

Mutations in the BRCA1 and BRCA2 genes significantly increase the risk of hereditary cancers, mainly of the breast and ovary, but also of other cancers such as those of the pancreas, prostate and cervix. In carriers of these mutations, multiple primary malignancies (MPM) represent a complex clinical challenge, influenced by genetic and environmental factors, as well as previous cancer treatments. The case reports a patient with a BRCA1 mutation with a family history of breast and ovarian cancer and who developed cervical cancer then recurrent triple-negative breast cancer treated with mastectomy, radiotherapy, chemotherapy and Poly (Adenosine diphosohate-ribose) polymérase inhibitors. This case underlines the interplay between different malignancies in the context of breast cancer mutations and the importance of specific and personalised treatment of patients with multiple primary malignancies.

Related Articles

Jessica O Esangbedo, Rachael O Oduyemi, Damilare Aduroja, Yetunde O Tola, Olajumoke Dele-Alonge, Emmanuel O Adesuyi, Michael O Ajiboye, Oluwadamilare Akingbade
Sushmita Rath, Mehak Trikha, Laboni Sarkar, Kunal Jobanputra, Akash Pawar, Revathy Krishnamurthy, Ayushi Sahay, Palak, Purvi Thakkar, Sneha Shah, Venkatesh Kapu, Anbarasan Sekar, Prabhat Bhargava, Seema Gulia, Rima Pathak, Tabassum Wadasadawala, Rajiv Sarin, Rajendra Badwe, Sudeep Gupta, Jyoti Bajpai
Izaberen Sampaio Estevam, Mariana Macambira Noronha, Júlia Matos Dubanhevitz, Eric Lima Freitas Mota, Ígor Giordan Duarte Jorge, Conceição Aparecida Dornelas, Diane Isabelle Magno Cavalcante, Georgia Fiuza Alencar Araripe, Márcio Marcondes Vieira
Agodirin Olayide, Chijioke Chijindu, Mustapha Fathi, Rahman Ganiyu, Olatoke Samuel, Olaogun Julius, Akande Halima