ecancermedicalscience

Research

Three-week hypofractionated radiotherapy in early glottic cancer – a single institution retrospective study

4 May 2022
Arun Sankar Sudha, Ravikumar Rejnish Kumar, Milan Anjanappa, Cessal Thomas Kainickal, Aleyamma Mathew, Ramadas Kunnambath

Background: Radiotherapy is a standard treatment option for early glottic carcinoma (stage I and II) with a fraction size of 2–2.2 Gy over 5–7 weeks. This study evaluates the outcome and prognostic factors of a 3-week hypofractionated treatment in early glottic malignancy.

Materials and Methods: The case records of 329 eligible patients with stage I and II glottic carcinoma recorded at the institution from 2003 to 2008 were retrospectively analysed. All patients were treated in a Cobalt-60 machine to a dose of 52.5 Gy in 15 fractions (3.5 Gy/fraction) over 3 weeks.

Results: Eighty-three percent had stage I disease. The local control rate at 5 years was 91.9%. On univariate analysis, stage I and II patients without subglottic extension had better local control. Disease extension to the subglottis fared poorly on multivariate analysis. After salvage treatment, the 5-year disease-free survival rate was 96.1% and the functional larynx preservation rate was 94.9% for stage I and 83.9% for stage II. The rate of severe complications was 2.1%.

Conclusion: Comparable results with low morbidity are achievable with a 3-week hypofractionation in early glottic cancers and it offers better patient convenience.

Highlights:

• In early glottic cancer, hypofractionated radiation provides excellent local control.

• Subglottic extension is a poor prognostic factor.

• 5-year disease-free survival rate of 96.1%.

• 5-year functional larynx preservation rate of 94.9%.

• Severe complication rate of 2.1%.

Related Articles

Samapika Bhaumik, Prarabdh Singh, Narapareddy Venkata Dinesh Reddy, Shreya Jain, Sambit S Nanda, Paramita Paul, Ashutosh Mukherji, Satyajit Pradhan
Olatunde Olaniyi Abiodun Oluwafemi, Eberechukwu Uchime Kasiemobi, Mustapha Babatunde, Bankole Kofi Adedeji, Oyelayo Oluwaseun Olaoluwa, Ismaheel Aderogba Azeez, Ezekpo Okechukwu Obumneme
Chase Peng Yun Ng, Moira Hegyi, Grant Lewison, Tania Pastrana, Eve Namisango, James Cleary, Barbara Hasties, Eric Kabisa, Helena Musau, Kathryn Spangenberg, Paola Ruiz, Zipporah Ali, Mertixell Mallafre-Larrosa, Alfredo Polo, Julie Torode, Ajay Aggarwal, Richard Sullivan, Mevhibe Hocaoglu