Short Communication

Oncological resection, myasthenia gravis and staging as prognostic factors in thymic tumours: a Chilean case series

9 Mar 2021
Patricio Salas, Maria Eliana Solovera, Felipe Bannura, Matias Muñoz-Medel, Miguel Cordova-Delgado, Cesar Sánchez, Carolina Ibáñez, Marcelo Garrido, Érica Koch, Francisco Acevedo, Sebastián Mondaca, Bruno Nervi, Jorge Madrid, José Peña, Mauricio P Pinto, José Valbuena, Héctor Galindo

Background: Thymic epithelial tumours are rare and highly heterogeneous. Reports from the United States suggest an overall incidence of 0.15 per 100,000/year. In contrast, the incidence of these tumours in Latin America is largely unknown and reports are scarce, somewhat limited to case reports.

Methods: Herein, we report a series of 38 thymic tumours from a single institution, retrospectively incorporated into this study. Patient characteristics and outcomes including age, sex, stage, paraneoplastic syndromes, treatment regimens and the date of decease were obtained from medical records.

Results: Most cases in our series were females and young age (<50 years old) and early stage by Masaoka-Koga or the Moran staging systems. Also, a 34% of patients had myasthenia gravis (MG). Next, we analysed overall survival rates in our series and found that the quality of surgery (R0, R1 or R2), MG status and staging (Masaoka-Koga, Moran or TNM) were prognostic factors. Finally, we compared our data to larger thymic tumour series.

Conclusions: Overall, our study confirms complete surgical resection as the standard, most effective treatment for thymic epithelial tumours. Also, the Masaoka-Koga staging system remains as a reliable prognostic factor but also the Moran staging system should be considered for thymomas.

Related Articles

Sonali Bagal, Atul Budukh, Jarnail Singh Thakur, Tapas Dora, Burhanuddin Qayyumi, Divya Khanna, Dolorosa Fernandes, Priyal Chakravarti, Ravikant Singh, Suvarna Patil, Rajesh Dikshit, Pankaj Chaturvedi
Lucas Avondet, Roque Adan, Barbara M Berenstein, Gonzalo Zeballos, Nicole Brasquet, Ángeles Da Silva, Candela Bazan, Gisela Coliva, Ximena Garcia
Lekha Madhavan Nair, John Mohan Mathew, Malu Rafi, Kainickal Cessal Thommachan, Jagathnath Krishna KM, Bipin T Varghese, Rejnish Ravikumar
Annie Kanchan Baa, Atul Sharma, Suman Bhaskar, Ahitagni Biswas, Alok Thakar, Rajeev Kumar, Sreeja Jayant, Gourishankar Aland, Alain D’Souza, Vikas Jadhav, Atul Bharde, Jayant Khandare, Raja Pramanik