ecancermedicalscience

Short Communication

Molecular characterisation of signalling pathways in cancer stem cells

2 Dec 2008
C Regenbrecht, Y Welte, A Jödicke, R Hugel, P Walden, M Jung, H Lehrach, J Adjaye

To avoid artefacts introduced by culturing cells for extended periods of time, it is crucial to use low-passage patient-derived tumour cells. The ability to enrich, isolate and assay sub-populations of cells that behave as cancer stem cells (CSCs) from these primary cell lines is essential before performing characterisations such as gene-expression profiling. We have isolated cells from glioblastomas which show characteristics of CSCs. Although glioblastomas contain only a relatively small amount of putative CSCs, these cells express many genes which seem to be worthy targets for future therapies.

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