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IMPAKT Breast Cancer Conference 2013 /
Breast cancer heterogeneity no barrier to predictive testing

2nd - 4th May 2013

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Published: 15.05.13
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Dr Michał Jarząb - Maria Skłodowska-Curie Institute of Oncology, Gliwice, Poland

ecancer reporter Peter Goodwin talks to Dr Jarząb at the 2013 IMPAKT conference in Brussels about a new study providing reassurance that the variability in different cell types with different patterns of gene expression should not be a barrier to using gene expression tests to help tailor cancer treatments to individual patients.

The researchers performed gene expression profiling on their 78 samples using oligonucleotide microarrays. Overall, they found that the gene expression profiles of the cores were variable, and in at least 5 patients this heterogeneity was substantial.

However, when they analysed a number of multi-gene signatures selected from previous studies, this heterogeneity was considerably less significant.

The gene sets differed in their variance between biopsies, the authors found. The most pronounced heterogeneity was observed in immune response-related genes, while the least heterogeneous were the classifiers based on genes selected by advanced bioinformatical methods from both cell culture experiments and patient tissues.

Read more here

ecancer's filming at IMPAKT has been kindly supported by Amgen through the ECMS Foundation. ecancer is editorially independent and there is no influence over content.

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation