There is a critical need for overcoming stigmas and enhancing awareness of childhood cancer in South Africa, where the underreporting and late diagnosis of cases significantly impact survival rates. Despite the global increase in childhood cancer cases, South Africa's statistics reveal a stark contrast, with only 70–80 children diagnosed per million, far below the expected incidence. The WHO's Global Initiative for Childhood Cancer aims for a 60% survival rate by 2030, highlighting the urgency of addressing these issues. South Africa’s late diagnosis of childhood cancer is impacted by prevalent myths surrounding childhood cancer, such as misconceptions about contagion and inheritance, which hinder early diagnosis and treatment compliance. The integration of traditional health practitioners into awareness campaigns is emphasised as a vital strategy for increasing referrals and reducing stigma. The role of civil society and patient advocates in implementing educational initiatives, including the Siluan Early Warning Signs of Cancer in Children, to improve awareness among healthcare workers and communities, acts as a catalyst for progress. These initiatives, often collaborative nature, undertaken by civil society and patient advocate groups to enhance knowledge, reduce stigma and create pilot initiatives build awareness in communities and kick-start political will to develop policies that can ensure a supportive environment for children with cancer and their families.