EHA 2021: Latest in immunotherapy for R/R multiple myeloma

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Published: 17 Jun 2021
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Prof Evangelos Terpos, Prof Heinz Ludwig, Prof Meral Beksac and Prof Michele Cavo

Prof Evangelos Terpos (University of Athens, Athens, Greece), Prof Heinz Ludwig (Wilhelmeninen Cancer Research Institute, Vienna, Austria), Prof Michele Cavo (Bologna University School of Medicine, Bologna, Italy) and Prof Meral Beksac (Ankara University Medical School, Ankara, Turkey) discuss the latest developments in the use of immunotherapy for relapsed or refractory multiple myeloma.

Prof Terpos starts the discussion by mentioning the real-world data for belantamab mafodotin treatment for patients with relapsed/refractory myeloma.

They then discuss the relationship between corneal exam findings, best-corrected visual acuity (BCVA), and ocular symptoms in patients with relapsed or refractory multiple myeloma (RRMM) receiving belantamab mafodotin.

The panel further talks about matching adjusted indirect comparison of ciltacabtagene autoleucel versus belantamab mafodotin in patients with relapsed/refractory multiple myeloma.

They also discuss the phase 1 study of elranatamab (PF-06863135), a B-cell maturation antigen targeted CD3-engaging bispecifc antibody, for patients with relapsed or refractory multiple myeloma.

They conclude by discussing the efficacy of isatuximab, carfilzomib, lenalidomide, and dexamethasone (ISA-KRD) in front-line treatment of high-risk multiple myeloma and isatuximab (ISA) plus pomalidomide and low-dose dexamethasone versus PD in relapsed and refractory multiple myeloma.

Belantamab Mafodotin treatment for patients with r/r myeloma: Real world data
Characterisation of ocular adverse events in patients receiving belantamab mafadotin for ≥12 months
Relationship between corneal exam findings, BCVA and ocular symptoms in patients with RRMM receiving belantamab mafodotin
Matching adjusted indirect comparison of ciltacabtagene autoleucel versus belantamab mafodotin in patients with RRMM
Elranatamab a BCMA targeted CD3-engaging bispecifc antibody, for patients with RRMM
Iberdomide in combination with dexamethasone and daratumumab, bortezomib, or carfilzomib in patients with RRMM
Updates from Icaria-MM study

 

This programme has been supported by an unrestricted educational grant from GSK.