OPTIC: A dose-ranging study of 3 starting doses of ponatinib for chronic-phase chronic myeloid leukaemia

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Published: 13 Jun 2020
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Prof Jorge Cortes - Augusta University, Augusta, USA

Prof Jorge Cortes speaks to ecancer in an online interview for the virtual EHA 2020 meeting.

He talks about the interim analysis from the OPTIC trial, a dose-ranging study of 3 starting doses of ponatinib for patients with chronic-phase chronic myeloid leukaemia (CP-CML).

Prof Cortes outlines the background and some detailed results from the study.

He highlights that this shows a trend toward dose-dependent efficacy and safety, and may provide a refined understanding of the ponatinib benefit/risk profile and its relation to dose.

Mature data from continued follow-up may support an alternate dosing regimen for patients with CP-CML.