Osimertinib plus gefitinib for treatment of EGFR-mutated non-small cell lung cancer

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Published: 12 Jun 2020
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Dr Julia Rotow - Dana Farber Cancer Institute, Boston, USA

Dr Julia Rotow talks to ecancer in an online interview for the ASCO 2020 virtual meeting about using concurrent osimertinib plus gefitinib for treating EGFR-mutated NSCLC.

The EGFR TKI osimertinib is active against the acquired gefitinib-resistant mutation EGFR T790M, as is gefitinib against the osimertinib-resistant EGFR C797S. Preclinical evidence suggests dual EGFR inhibition with gefitinib osimertinib may delay emergence of acquired resistance.

Dr Rotow outlines the trial design and results, and how this regimen will impact clinical practice.