Dr Cazzaniga speaks with ecancer about the prenatal origin of acute lymphoblastic leukaemia.

He describes how Guthrie card analysis has identified mutations in utero, 1% of which manifests as ALL, and compares this to the rate of concordant mutations in twins.

Dr Cazzaniga emphasises that such mutations are seemingly unpreventable, and do not reflect the genotype of either parent, though ongoing monitoring of a concordant and discordant twins is encouraged.

ecancer's filming has been kindly supported by Amgen through the ECMS Foundation. ecancer is editorially independent and there is no influence over content.